源自青霉状曲霉的两种新型吲哚二酮哌嗪类化合物，曲匹他汀C和D
Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.
作者信息
Zhang Han, Zhu Hong-Tao, Wang Dong, Yang Chong-Ren, Zhang Ying-Jun
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
Nat Prod Bioprospect. 2018 Apr;8(2):107-111. doi: 10.1007/s13659-018-0156-z. Epub 2018 Mar 14.
Twelve indolyl diketopiperazines 1-12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2) featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds, while 3 and 4 were obtained for the first time from nature source. The isolates 3-12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40 μM.
从普洱茶后发酵过程中的优势微生物——青霉状曲霉（Aspergillus penicilliodes Speg.）的菌丝体培养物中分离得到了12种吲哚二酮哌嗪类化合物1-12。通过广泛的光谱方法对其结构进行了阐明。其中，在C-2位具有罕见甲基乙烯基酮侧链的曲抑菌素C（1）和D（2）为新化合物，而3和4是首次从天然来源获得。在浓度为40 μM时，分离得到的化合物3-12对五种人类癌细胞系未表现出明显的细胞毒性。
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