State Key Laboratory of Functions and Applications of Medicinal Plants , Guizhou Medical University , Guiyang , Guizhou 550014 , China.
Key Laboratory of Chemistry for Natural Products of Guizhou Province , Chinese Academy of Sciences , Guiyang , Guizhou 550014 , China.
J Agric Food Chem. 2019 Sep 25;67(38):10660-10666. doi: 10.1021/acs.jafc.9b04254. Epub 2019 Sep 10.
Two new indolyl diketopiperazines, gartryprostatins A and B ( and ), with an unusual 2,3-furan-fused pyrano[2,3-]pyrrolo[1″,2″:4',5']pyrazino[1',2':1,5]pyrrolo[2,3-]indole nucleus, along with a new naturally occurring compound (gartryprostatin C, ) were isolated from the solid culture of sp. GZWMJZ-258, an endophyte from (Guttiferae). The structures of compounds - were determined by nuclear magnetic resonance, mass spectrometry, Marfey's analysis of amino acids, and chemical calculation. Compounds - displayed selective inhibition on human FLT3-ITD mutant AML cell line, MV4-11, with IC values of 7.2, 10.0, and 0.22 μM, respectively.
从内生真菌 sp. GZWMJZ-258 的固体培养物中分离得到两种新的吲哚二酮哌嗪类化合物，即 gartryprostatins A 和 B（ 和 ），以及一种新的天然化合物（gartryprostatin C， ）。化合物 - 的结构通过核磁共振、质谱、氨基酸的 Marfey 分析和化学计算确定。化合物 - 对人 FLT3-ITD 突变型 AML 细胞株 MV4-11 表现出选择性抑制作用，IC 值分别为 7.2、10.0 和 0.22 μM。
