性交时使用润滑剂与妊娠时间：一项前瞻性队列研究。

Lubricant use during intercourse and time to pregnancy: a prospective cohort study.

机构信息

Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

出版信息

BJOG. 2018 Nov;125(12):1541-1548. doi: 10.1111/1471-0528.15218. Epub 2018 Apr 15.

DOI:10.1111/1471-0528.15218

PMID:29543376

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6139089/

Abstract

OBJECTIVE

To assess the extent to which lubricant use during intercourse is associated with time to pregnancy (TTP).

DESIGN

Prospective cohort study.

SETTING

Denmark and North America.

POPULATION

A total of 6467 women aged 18-49 years who were not using contraception or fertility treatment.

METHODS

We pooled data from two continuing prospective cohort studies of pregnancy planners in Denmark (2011-2017) and North America (2013-2017). Female participants completed bimonthly questionnaires for 12 months or until they reported pregnancy. After restricting the study to women without a history of infertility who had been trying to conceive for six or fewer cycles at enrollment, 6467 women were retained for analysis. Self-reported lubricant use was categorised as water-based/not pH balanced, water-based/pH balanced 'fertility friendly', silicone-based, oil-based, or a combination of these. We used proportional probability models to calculate fecundability ratios (FRs) and 95% confidence intervals (95% CIs) for the association between lubricant use and fecundability, after adjusting for cohort and sociodemographic and lifestyle factors.

MAIN OUTCOME MEASURE

Fecundability.

RESULTS

At baseline, 17.5% of participants reported the use of lubricants, most commonly water-based/not pH balanced (11.4%). Compared with non-use of lubricants, FRs were 1.02 (95% CI 0.93-1.11) for water-based/not pH-balanced lubricant use, 1.01 (95% CI 0.86-1.18) for water-based/pH balanced 'fertility friendly' lubricant use, 1.23 (95% CI 0.94-1.61) for oil-based lubricant use, and 1.27 (95% CI 0.93-1.73) for silicone-based lubricant use. Associations between oil-based lubricant use and fecundability were inconsistent across subgroups of study cohort, age, parity, and intercourse frequency.

CONCLUSIONS

Lubricant use was not associated with reduced fecundability in the preconception cohorts of pregnancy planners studied.

TWEETABLE ABSTRACT

Lubricant use during intercourse was not associated with time to pregnancy in a study of pregnancy planners.

摘要

目的

评估性交时使用润滑剂与妊娠时间（TTP）之间的关系。

设计

前瞻性队列研究。

地点

丹麦和北美。

人群

6467 名年龄在 18-49 岁之间、未使用避孕措施或生育治疗的女性。

方法

我们汇总了丹麦（2011-2017 年）和北美（2013-2017 年）两个妊娠计划者持续前瞻性队列研究的数据。女性参与者完成了为期 12 个月的双月问卷，或直到报告怀孕。在将研究限制在没有不孕史且在入组时已尝试怀孕 6 个周期或更短时间的女性后，保留了 6467 名女性进行分析。自我报告的润滑剂使用情况分为水基/非 pH 平衡、水基/pH 平衡“生育友好型”、硅基、油基或这些的组合。我们使用比例概率模型来计算润滑剂使用与生育能力之间的关系的生育能力比（FR）和 95%置信区间（95%CI），并在调整队列和社会人口学及生活方式因素后进行分析。

主要观察指标

生育能力。

结果

在基线时，17.5%的参与者报告使用了润滑剂，最常见的是水基/非 pH 平衡（11.4%）。与不使用润滑剂相比，水基/非 pH 平衡润滑剂使用的 FR 为 1.02（95%CI 0.93-1.11），水基/pH 平衡“生育友好型”润滑剂使用的 FR 为 1.01（95%CI 0.86-1.18），油基润滑剂使用的 FR 为 1.23（95%CI 0.94-1.61），硅基润滑剂使用的 FR 为 1.27（95%CI 0.93-1.73）。在研究队列、年龄、产次和性交频率的亚组中，油基润滑剂使用与生育能力之间的关联不一致。