Grimaldi R, Zini I, Agnati F, Fuxe K, Härfstrand A
Acta Physiol Scand. 1987 Apr;129(4):525-8. doi: 10.1111/j.1748-1716.1987.tb08092.x.
The effects of intravenous administration of various doses of atriopeptin III (0.4-36 nmol kg-1) on arterial blood pressure, urinary flow and Na+ and K+ excretion were analysed in awake animals. A dose-related reduction of arterial blood pressure was obtained in 4- and 24-month-old unrestrained, freely moving male rats. A dose-related increase in the diuresis and in sodium and potassium excretion was present in both young and old rats. The hypotensive action was significantly prolonged in the aged animals, indicating possible alterations in the control of the cardiovascular system by the endocrine activity of the heart in the old animal.
在清醒动物中分析了静脉注射不同剂量的心房肽III（0.4 - 36 nmol·kg⁻¹）对动脉血压、尿流量以及钠和钾排泄的影响。在4个月和24个月大的无束缚、自由活动的雄性大鼠中，获得了与剂量相关的动脉血压降低。年轻和老年大鼠的利尿以及钠和钾排泄均出现与剂量相关的增加。老年动物的降压作用明显延长，表明老年动物心脏内分泌活动对心血管系统的调控可能发生了改变。
