Malik Misbah, Tasnim Nasira, Mahmud Ghazala
Department of Obstetrics and Gynaecology, Maternal and Child Health Centre, Unit II, Pakistan Institute of Medical Sciences (PIMS), Islamabad.
J Coll Physicians Surg Pak. 2018 Mar;28(3):184-187. doi: 10.29271/jcpsp.2018.03.184.
To determine the efficacy of metformin alone versus metformin plus simvastatin for treatment of polycystic ovariansyndrome (PCOS).
Randomized controlled trial.
Maternal and Child Health Centre, Unit II, Pakistan Institute of Medical Sciences (PIMS), from November 2014 to April 2015.
One hundred and eight patients (108) were randomly divided into metformin group (n=54) and metformin plus simvastatin group (n=54), detailed clinical history, including menstrual details, was taken with thorough examination performed. Baseline ultrasound was performed to evaluate ovarian size and these were considered enlarged with volume >10cc or with >12 follicles in any one ovary. Blood samples were taken at baseline and after three months of therapy to determine the LH/FSH ratio and lipid profile. Efficacy was defined as >15% decrease in the baseline values.
The mean age of patients was 28.82 ±7.18 years. Mean BMI of the patients was 22.41 ±1.55 Kg/m2. Efficacy was achieved in 66.7% patients with metformin alone, while in 92.6% with combination medication (p=0.001).
The combination of metformin plus simvastatin is more efficacious as compared to metformin alone for management of females with PCOS.
确定单独使用二甲双胍与二甲双胍加辛伐他汀治疗多囊卵巢综合征（PCOS）的疗效。
随机对照试验。
2014年11月至2015年4月，巴基斯坦医学科学研究所（PIMS）第二单元母婴健康中心。
108例患者被随机分为二甲双胍组（n = 54）和二甲双胍加辛伐他汀组（n = 54），详细记录临床病史，包括月经情况，并进行全面检查。进行基线超声检查以评估卵巢大小，若任何一侧卵巢体积>10cc或有>12个卵泡，则认为卵巢增大。在基线和治疗三个月后采集血样，以测定LH/FSH比值和血脂谱。疗效定义为基线值降低>15%。
患者的平均年龄为28.82±7.18岁。患者的平均BMI为22.41±1.55 Kg/m2。单独使用二甲双胍的患者中66.7%取得了疗效，而联合用药的患者中这一比例为92.6%（p = 0.001）。
对于PCOS女性患者的管理，二甲双胍加辛伐他汀联合用药比单独使用二甲双胍更有效。
