Otsuka Fumio
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Vitam Horm. 2018;107:137-153. doi: 10.1016/bs.vh.2018.01.012.
The bone morphogenetic protein (BMP) system in the ovary plays a physiological role as a luteinization inhibitor in growing follicles. BMP-6 secreted from oocytes and granulosa cells can exert an inhibitory effect on follicle-stimulating hormone (FSH) actions by suppressing adenylate cyclase activity downstream of the FSH receptor. The inhibition of FSH-induced progesterone production by BMP-6 is impaired by melatonin treatment in granulosa cells. Intracellular Smad signaling induced by BMP-6 is suppressed by melatonin, suggesting that melatonin has a regulatory role in BMP receptor signaling in granulosa cells. Since the expression of BMP-6 in granulosa cells is increased in patients with polycystic ovary syndrome, melatonin may play an important role in the maintenance of progesterone production by suppressing BMP-6 signaling, leading to the preservation of ovarian function.
卵巢中的骨形态发生蛋白（BMP）系统在生长卵泡中作为黄体化抑制剂发挥生理作用。卵母细胞和颗粒细胞分泌的BMP-6可通过抑制FSH受体下游的腺苷酸环化酶活性，对促卵泡激素（FSH）的作用产生抑制效应。在颗粒细胞中，褪黑素处理可削弱BMP-6对FSH诱导的孕酮生成的抑制作用。褪黑素可抑制BMP-6诱导的细胞内Smad信号，提示褪黑素在颗粒细胞的BMP受体信号传导中具有调节作用。由于多囊卵巢综合征患者颗粒细胞中BMP-6的表达增加，褪黑素可能通过抑制BMP-6信号传导在维持孕酮生成中发挥重要作用，从而有助于维持卵巢功能。
