Yuan Xingxing, Wang Bingyu, Yang Lei, Zhang Yali
Department of Gastroenterology, Nangang branch of Heilongjiang Academy of Traditional Chinese Medicine, No. 33 West Dazhi Road, Nangang District, Harbin, Heilongjiang 150006, China.
Department of Gastroenterology, Nangang branch of Heilongjiang Academy of Traditional Chinese Medicine, No. 33 West Dazhi Road, Nangang District, Harbin, Heilongjiang 150006, China.
Clin Res Hepatol Gastroenterol. 2018 Sep;42(4):306-312. doi: 10.1016/j.clinre.2018.01.005. Epub 2018 Mar 12.
Hepatocellular carcinoma (HCC) is a main cause of cancer-related mortality and its etiology is not fully understood. As prominent factors that regulate cellular homeostasis, both reactive oxygen species (ROS) and autophagy are considered to play an essential role in the liver carcinogenesis. However, the crosstalk between ROS and autophagy is not well characterized in the pathogenesis of HCC. This review summarizes the roles of autophagy in ROS-mediated hepatocarcinogenesis and discusses the role of ROS-induced autophagy in HCC cell fate decision following treatment with chemotherapeutic agents in preclinical settings, which may allow the identification of novel strategies for the treatment of HCC.
肝细胞癌（HCC）是癌症相关死亡的主要原因，其病因尚未完全明确。作为调节细胞稳态的重要因素，活性氧（ROS）和自噬均被认为在肝癌发生过程中起着至关重要的作用。然而，ROS与自噬之间的相互作用在HCC发病机制中尚未得到充分阐明。本综述总结了自噬在ROS介导的肝癌发生中的作用，并讨论了在临床前环境中，ROS诱导的自噬在化疗药物治疗后HCC细胞命运决定中的作用，这可能有助于确定治疗HCC的新策略。
