• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

光触发结构：生物医学应用的最新进展。

Phototriggered structures: Latest advances in biomedical applications.

作者信息

Shamsipur Mojtaba, Ghavidast Atefeh, Pashabadi Afshin

机构信息

Department of Chemistry, Razi University, Kermanshah 6714414971, Iran.

出版信息

Acta Pharm Sin B. 2023 Jul;13(7):2844-2876. doi: 10.1016/j.apsb.2023.04.005. Epub 2023 Apr 17.

DOI:10.1016/j.apsb.2023.04.005
PMID:37521863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10372844/
Abstract

Non-invasive control of the drug molecules accessibility is a key issue in improving diagnostic and therapeutic procedures. Some studies have explored the spatiotemporal control by light as a peripheral stimulus. Phototriggered drug delivery systems (PTDDSs) have received interest in the past decade among biological researchers due to their capability the control drug release. To this end, a wide range of phototrigger molecular structures participated in the DDSs to serve additional efficiency and a high-conversion release of active fragments under light irradiation. Up to now, several categories of PTDDSs have been extended to upgrade the performance of controlled delivery of therapeutic agents based on well-known phototrigger molecular structures like -nitrobenzyl, coumarinyl, anthracenyl, quinolinyl, -hydroxycinnamate and hydroxyphenacyl, where either of one endows an exclusive feature and distinct mechanistic approach. This review conveys the design, photochemical properties and essential mechanism of the most important phototriggered structures for the release of single and dual (similar or different) active molecules that have the ability to quickly reason of the large variety of dynamic biological phenomena for biomedical applications like photo-regulated drug release, synergistic outcomes, real-time monitoring, and biocompatibility potential.

摘要

药物分子可及性的非侵入性控制是改善诊断和治疗程序的关键问题。一些研究探索了将光作为一种外周刺激进行时空控制。在过去十年中，光触发药物递送系统（PTDDSs）因其控制药物释放的能力而受到生物研究人员的关注。为此，各种各样的光触发分子结构参与到药物递送系统中，以在光照射下实现更高的效率和活性片段的高转化率释放。到目前为止，几类PTDDSs已得到扩展，以提升基于诸如对硝基苄基、香豆素基、蒽基、喹啉基、肉桂酸酯基和羟苯甲酰基等著名光触发分子结构的治疗剂控释性能，其中每一种都赋予了独特的特性和不同的作用机制。本综述阐述了用于释放单一和双（相似或不同）活性分子的最重要光触发结构的设计、光化学性质和基本机制，这些结构能够快速解释用于生物医学应用（如光调控药物释放、协同效应、实时监测和生物相容性潜力）的各种动态生物学现象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/65c5bc1cf8f4/sc25.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/826a78f72f88/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/ceba4d0694c1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/41269364fe74/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/1d24ecd2b916/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/485b9292e004/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/221c62b019ed/sc2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/94cfba5fbaa8/sc3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/e1b22596e502/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/09f7f98812a9/sc4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/db488574053c/sc5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/f1d6f2e3e56c/sc24.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/72594b45e6b9/sc6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/1371c087836c/sc7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/4db91f74f09c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/152971697363/sc8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/5d266bca45bf/sc9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/df29fd9f0e22/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/5d38b6321ddc/sc10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/8eb8172a97ba/sc11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/8c350f3d5f92/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/522cdfecf82e/sc12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/523088ff2eca/sc13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/6e952113acf6/sc14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/3b5fbbadef14/sc15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/49eb569e6b90/sc16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/7c46409ee688/sc17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/68307ec8518a/sc18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/e3d7c2d0cbea/sc19.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/1f5daabaf26c/sc20.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/77c4af8b8f6c/sc21.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/ef2145a9ace0/sc22.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/221bcc879cfb/sc23.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/65c5bc1cf8f4/sc25.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/826a78f72f88/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/ceba4d0694c1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/41269364fe74/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/1d24ecd2b916/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/485b9292e004/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/221c62b019ed/sc2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/94cfba5fbaa8/sc3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/e1b22596e502/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/09f7f98812a9/sc4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/db488574053c/sc5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/f1d6f2e3e56c/sc24.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/72594b45e6b9/sc6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/1371c087836c/sc7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/4db91f74f09c/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/152971697363/sc8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/5d266bca45bf/sc9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/df29fd9f0e22/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/5d38b6321ddc/sc10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/8eb8172a97ba/sc11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/8c350f3d5f92/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/522cdfecf82e/sc12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/523088ff2eca/sc13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/6e952113acf6/sc14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/3b5fbbadef14/sc15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/49eb569e6b90/sc16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/7c46409ee688/sc17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/68307ec8518a/sc18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/e3d7c2d0cbea/sc19.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/1f5daabaf26c/sc20.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/77c4af8b8f6c/sc21.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/ef2145a9ace0/sc22.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/221bcc879cfb/sc23.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b861/10372844/65c5bc1cf8f4/sc25.jpg

相似文献

1
Phototriggered structures: Latest advances in biomedical applications.光触发结构：生物医学应用的最新进展。
Acta Pharm Sin B. 2023 Jul;13(7):2844-2876. doi: 10.1016/j.apsb.2023.04.005. Epub 2023 Apr 17.
2
Photoresponsive real time monitoring silicon quantum dots for regulated delivery of anticancer drugs.用于调控抗癌药物递送的光响应实时监测硅量子点
J Mater Chem B. 2016 Jan 21;4(3):521-528. doi: 10.1039/c5tb02045j. Epub 2015 Dec 18.
3
ESIPT-, AIE-, and AIE + ESIPT-Based Light-Activated Drug Delivery Systems and Bioactive Donors for Targeted Disease Treatment.基于 ESIPT、AIE 和 AIE + ESIPT 的光激活药物传递系统和用于靶向疾病治疗的生物活性供体。
J Med Chem. 2023 Mar 23;66(6):3732-3745. doi: 10.1021/acs.jmedchem.2c01466. Epub 2023 Mar 13.
4
Recent Advances in Metal-Organic Frameworks as Anticancer Drug Delivery Systems: A Review.金属有机框架作为抗癌药物传递系统的最新进展：综述。
Anticancer Agents Med Chem. 2021;21(18):2487-2504. doi: 10.2174/1871520621666210119093844.
5
ESIPT-induced fluorescent o-hydroxycinnamate: a self-monitoring phototrigger for prompt image-guided uncaging of alcohols.基于激发态分子内质子转移（ESIPT）的荧光邻羟基肉桂酸酯：一种用于快速图像引导醇类物质解笼的自监测光触发剂。
Org Biomol Chem. 2017 Oct 18;15(40):8544-8552. doi: 10.1039/c7ob02280h.
6
Single component photoresponsive fluorescent organic nanoparticles: a smart platform for improved biomedical and agrochemical applications.单组分光响应荧光有机纳米粒子：用于改善生物医学和农用化学品应用的智能平台。
Chem Commun (Camb). 2021 Feb 18;57(14):1715-1733. doi: 10.1039/d0cc07183h. Epub 2021 Jan 27.
7
Photo-controlled Zn(2+) release system with dual binding-sites and turn-on fluorescence.具有双结合位点和荧光开启的光控 Zn(2+)释放体系。
Phys Chem Chem Phys. 2010 Feb 7;12(5):1177-81. doi: 10.1039/b917948h. Epub 2009 Dec 23.
8
Macromolecular crowding: chemistry and physics meet biology (Ascona, Switzerland, 10-14 June 2012).大分子拥挤现象：化学与物理邂逅生物学（瑞士阿斯科纳，2012年6月10日至14日）
Phys Biol. 2013 Aug;10(4):040301. doi: 10.1088/1478-3975/10/4/040301. Epub 2013 Aug 2.
9
A p-Hydroxyphenacyl-Benzothiazole-Chlorambucil Conjugate as a Real-Time-Monitoring Drug-Delivery System Assisted by Excited-State Intramolecular Proton Transfer.一种对羟基苯甲酰基 - 苯并噻唑 - 苯丁酸氮芥共轭物作为由激发态分子内质子转移辅助的实时监测药物递送系统
Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4194-8. doi: 10.1002/anie.201508901. Epub 2016 Feb 25.
10
Phototriggered Supramolecular Polymerization.光触发超分子聚合
Chemistry. 2016 Nov 14;22(47):16872-16877. doi: 10.1002/chem.201603691. Epub 2016 Oct 13.

引用本文的文献

1
Tautomerism and switching in 7-hydroxy-8-(azophenyl)quinoline and similar compounds.7-羟基-8-（偶氮苯基）喹啉及类似化合物中的互变异构和转换
Beilstein J Org Chem. 2025 Jul 10;21:1404-1421. doi: 10.3762/bjoc.21.105. eCollection 2025.
2
Size-transformable nanotherapeutics for cancer therapy.用于癌症治疗的尺寸可变换纳米治疗剂。
Acta Pharm Sin B. 2025 Feb;15(2):834-851. doi: 10.1016/j.apsb.2024.11.012. Epub 2024 Nov 25.
3
Ultraviolet (UV) radiation: a double-edged sword in cancer development and therapy.紫外线（UV）辐射：在癌症发展和治疗中的双刃剑。

本文引用的文献

1
Enzyme-Responsive COF-Based Thiol-Targeting Nanoinhibitor for Curing Bacterial Infections.基于 COF 的酶响应型硫醇靶向纳米抑制剂用于治疗细菌感染。
ACS Appl Mater Interfaces. 2022 Aug 31;14(34):38483-38496. doi: 10.1021/acsami.2c08845. Epub 2022 Aug 21.
2
Promoting Mechanochemistry of Covalent Bonds by Noncovalent Micellar Aggregation.通过非共价胶束聚集促进共价键的机械化学
ACS Macro Lett. 2016 Sep 20;5(9):995-998. doi: 10.1021/acsmacrolett.6b00579. Epub 2016 Aug 8.
3
Light-Triggered Switching of Reversible and Alterable Biofunctionality via β-Cyclodextrin/Azobenzene-Based Host-Guest Interaction.
Mol Biomed. 2024 Oct 17;5(1):49. doi: 10.1186/s43556-024-00209-8.
4
Aptamer-Based Smart Targeting and Spatial Trigger-Response Drug-Delivery Systems for Anticancer Therapy.用于抗癌治疗的基于适配体的智能靶向和空间触发响应药物递送系统
Biomedicines. 2024 Jan 15;12(1):187. doi: 10.3390/biomedicines12010187.
通过基于β-环糊精/偶氮苯的主客体相互作用实现可逆且可改变生物功能的光触发切换
ACS Macro Lett. 2014 Nov 18;3(11):1130-1133. doi: 10.1021/mz500568k. Epub 2014 Oct 16.
4
Dithienylethene-Bridged Fluoroquinolone Derivatives for Imaging-Guided Reversible Control of Antibacterial Activity.二噻烯并桥连氟喹诺酮衍生物用于成像引导的抗菌活性的可逆控制。
J Org Chem. 2022 Jun 3;87(11):7446-7455. doi: 10.1021/acs.joc.2c00797. Epub 2022 May 24.
5
Photoinduced Polymer Chain Scission of Alkoxyphenacyl Based Polycarbonates.基于烷氧基苯甲酰基的聚碳酸酯的光致聚合物链断裂
ACS Macro Lett. 2012 Oct 16;1(10):1184-1188. doi: 10.1021/mz3002947. Epub 2012 Sep 21.
6
Mechanochemical Strengthening of a Multi-mechanophore Benzocyclobutene Polymer.多机械发色团苯并环丁烯聚合物的机械化学强化
ACS Macro Lett. 2015 Aug 18;4(8):834-837. doi: 10.1021/acsmacrolett.5b00440. Epub 2015 Jul 20.
7
Comparison of Mechanochemical Chain Scission Rates for Linear versus Three-Arm Star Polymers in Strong Acoustic Fields.强声场中线性聚合物与三臂星形聚合物的机械化学断链速率比较
ACS Macro Lett. 2014 Jul 15;3(7):648-651. doi: 10.1021/mz5003068. Epub 2014 Jun 17.
8
Mechanochemical Activation of Covalent Bonds in Polymers with Full and Repeatable Macroscopic Shape Recovery.具有完全且可重复的宏观形状恢复能力的聚合物中共价键的机械化学活化
ACS Macro Lett. 2014 Mar 18;3(3):216-219. doi: 10.1021/mz500031q. Epub 2014 Feb 12.
9
Triggered azobenzene-based prodrugs and drug delivery systems.基于偶氮苯的前药和药物传递系统。
J Control Release. 2022 May;345:475-493. doi: 10.1016/j.jconrel.2022.03.041. Epub 2022 Mar 23.
10
Naphthalimide-Based Azo-Functionalized Supramolecular Vesicle in Hypoxia-Responsive Drug Delivery.基于萘酰亚胺的偶氮功能化超分子囊泡用于缺氧响应性药物递送。
Langmuir. 2022 Mar 22;38(11):3480-3492. doi: 10.1021/acs.langmuir.1c03334. Epub 2022 Mar 9.