Department of Psychology, University of Maine, Orono, ME; Department of Psychology, Harvard University, Cambridge, MA.
Department of Psychology, Harvard University, Cambridge, MA.
Arch Phys Med Rehabil. 2018 Aug;99(8):1576-1583. doi: 10.1016/j.apmr.2018.02.008. Epub 2018 Mar 12.
To investigate the relation between posttraumatic stress (PTS) symptom severity and health-related quality of life (HRQoL) after severe traumatic brain injury (TBI).
Longitudinal prospective multicenter, cohort study on severe TBI in Switzerland (2007-2011).
Hospital, rehabilitation unit, and/or patient's living facility.
Patients with severe TBI (N=109) were included in the analyses. Injury severity was determined using the Abbreviated Injury Score of the head region after clinical assessment and initial computed tomography scan.
Not applicable.
HRQoL (Medical Outcomes Study 12-Item Short-Form Health Survey Physical and Mental Component Summaries) and self-reported emotional, cognitive, and interpersonal functioning (Patient Competency Rating Scale for Neurorehabilitation).
Multilevel models for patients >50 and ≤50 years of age revealed significant negative associations between PTS symptom severity and interpersonal functioning (P<.001 and P=.002), respectively. Among patients ≤50 years of age, PTS symptom severity was significantly associated with total functioning (P=.001) and emotional functioning (P<.001). Among all patients, PTS symptom severity was significantly associated with cognitive functioning (P<.001) and mental HRQoL (P=.01).
Findings indicate that PTS symptoms after severe TBI are negatively associated with HRQoL and emotional, cognitive, and interpersonal functioning.
研究创伤后应激（PTS）症状严重程度与严重创伤性脑损伤（TBI）后健康相关生活质量（HRQoL）的关系。
瑞士严重 TBI 的前瞻性纵向多中心队列研究（2007-2011 年）。
医院、康复单位和/或患者生活场所。
严重 TBI 患者（N=109）纳入分析。损伤严重程度采用临床评估和初始 CT 扫描后头部区域的简明损伤评分确定。
不适用。
HRQoL（医疗结局研究 12 项简明健康调查量表的生理和心理成分总结）和自我报告的情绪、认知和人际功能（神经康复患者能力评定量表）。
50 岁和≤50 岁患者的多水平模型显示，PTS 症状严重程度与人际关系功能呈显著负相关（P<.001 和 P=.002）。在≤50 岁的患者中，PTS 症状严重程度与总功能（P=.001）和情绪功能（P<.001）显著相关。所有患者中，PTS 症状严重程度与认知功能（P<.001）和心理 HRQoL（P=.01）显著相关。
研究结果表明，严重 TBI 后 PTS 症状与 HRQoL 以及情绪、认知和人际关系功能呈负相关。
