Postnov A Iu
Arkh Patol. 1987;49(3):86-90.
The author reviews some literature data available on discovery, morphology and physiology of the atrial natriuretic factor (ANF) with special emphasis on the morphology of specific ANF granules, mechanisms of secretion and deposition in cardiomyocytes. The granules formation during embryogenesis, ANF structure and physiologic effect on the kidney, smooth muscles, renin-angiotensin-aldosterone system are analysed. Molecular mechanisms of ANF action are suggested. Current knowledge about ANF system significance in the genesis of some disorders, arterial hypertension in particular, is evaluated.
作者回顾了一些关于心房利钠因子（ANF）的发现、形态学和生理学的文献资料，特别强调了特定ANF颗粒的形态学、分泌机制以及在心肌细胞中的沉积。分析了胚胎发育过程中的颗粒形成、ANF结构以及对肾脏、平滑肌、肾素 - 血管紧张素 - 醛固酮系统的生理作用。提出了ANF作用的分子机制。评估了目前关于ANF系统在某些疾病，特别是动脉高血压发生过程中的意义的认识。
