de Bold A J
Fed Proc. 1986 Jun;45(7):2081-5.
Heart atrial muscle cells in mammals are differentiated for a contractile as well as a secretory function. Through the latter, the heart plays an endocrine role; it synthesizes, stores, and releases a group of peptides collectively referred to as atrial natriuretic factor (ANF). ANF has natriuretic and hypotensive properties as well as an inhibitory effect on aldosterone and renin secretion. Thus ANF intervenes in the short- and long-term regulation of water and electrolyte balance and blood pressure. It is expected that further research in this new field will provide fresh insights into the pathophysiology of several important clinical entities and in the development of new pharmaceutical products.
哺乳动物的心房肌细胞具有收缩和分泌功能。通过后者，心脏发挥内分泌作用；它合成、储存并释放一组统称为心房利钠因子（ANF）的肽。ANF具有利钠和降压特性，以及对醛固酮和肾素分泌的抑制作用。因此，ANF参与水和电解质平衡以及血压的短期和长期调节。预计在这个新领域的进一步研究将为几种重要临床病症的病理生理学以及新药物产品的开发提供新的见解。
