肺血管内皮：呼吸疾病中的管弦乐队指挥：基础研究到治疗的亮点。
Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases: Highlights from basic research to therapy.
机构信息
INSERM UMR_S 999, Hôpital Marie Lannelongue, Université Paris-Sud/Université Paris-Saclay, AP-HP, Service de Pneumologie, Centre de Référence de l'Hypertension Pulmonaire Sévère, DHU Thorax Innovation, Hôpital Bicêtre, Le Plessis-Robinson and Le Kremlin-Bicêtre, France.
A. Huertas and C. Guignabert have contributed equally. They are both first authors and are co-chairs of the European Respiratory Society (ERS) Research Seminar Faculty.
出版信息
Eur Respir J. 2018 Apr 4;51(4). doi: 10.1183/13993003.00745-2017. Print 2018 Apr.
The European Respiratory Society (ERS) Research Seminar entitled "Pulmonary vascular endothelium: orchestra conductor in respiratory diseases - highlights from basic research to therapy" brought together international experts in dysfunctional pulmonary endothelium, from basic science to translational medicine, to discuss several important aspects in acute and chronic lung diseases. This review will briefly sum up the different topics of discussion from this meeting which was held in Paris, France on October 27-28, 2016. It is important to consider that this paper does not address all aspects of endothelial dysfunction but focuses on specific themes such as: 1) the complex role of the pulmonary endothelium in orchestrating the host response in both health and disease (acute lung injury, chronic obstructive pulmonary disease, high-altitude pulmonary oedema and pulmonary hypertension); and 2) the potential value of dysfunctional pulmonary endothelium as a target for innovative therapies.
欧洲呼吸学会（ERS）研究研讨会题为“肺血管内皮：呼吸疾病的管弦乐队指挥——基础研究到治疗的亮点”汇集了国际上在功能失调的肺内皮方面的专家，从基础科学到转化医学，讨论了急性和慢性肺部疾病的几个重要方面。本文简要总结了 2016 年 10 月 27 日至 28 日在法国巴黎举行的会议的不同讨论主题。需要指出的是，本文并没有涉及内皮功能障碍的所有方面，而是侧重于特定主题，如：1）肺内皮在健康和疾病（急性肺损伤、慢性阻塞性肺疾病、高原肺水肿和肺动脉高压）中协调宿主反应的复杂作用；2）功能失调的肺内皮作为创新治疗靶点的潜在价值。
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