Department of Radiology and Program in Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, New York.
Department of Chemistry, Hunter College, New York, New York.
J Nucl Med. 2018 Jul;59(7):1020-1027. doi: 10.2967/jnumed.117.204651. Epub 2018 Mar 1.
The use of radioactive sources to deliver cytotoxic ionizing radiation to disease sites dates back to the early 20th century, with the discovery of radium and its physiologic effects. α-emitters are of particular interest in the field of clinical oncology for radiotherapy applications. The first part of this review explored the basic radiochemistry, high cell-killing potency, and availability of α-emitting radionuclides, together with hurdles such as radiolabeling methods and daughter redistribution. The second part of this review will give an overview of the most promising and current uses of α-emitters in preclinical and clinical studies.
放射性核素用于将细胞毒性电离辐射递送至疾病部位可以追溯到 20 世纪初，当时发现了镭及其生理效应。α-发射体在临床肿瘤学的放射治疗应用中特别有意义。本综述的第一部分探讨了基础放射化学、高细胞杀伤效力和α发射放射性核素的可用性，以及放射性标记方法和子体再分布等障碍。本综述的第二部分将概述α发射体在临床前和临床研究中的最有前途和当前用途。
