• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

嗜铬细胞瘤的当前诊断成像及其对治疗策略的影响。

Current diagnostic imaging of pheochromocytomas and implications for therapeutic strategy.

作者信息

Čtvrtlík Filip, Koranda Pavel, Schovánek Jan, Škarda Jozef, Hartmann Igor, Tüdös Zbyněk

机构信息

Department of Radiology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.

Department of Nuclear Medicine, University Hospital and Faculty of Medicine and Dentistry, Palacky University, 779 00 Olomouc, Czech Republic.

出版信息

Exp Ther Med. 2018 Apr;15(4):3151-3160. doi: 10.3892/etm.2018.5871. Epub 2018 Feb 14.

DOI:10.3892/etm.2018.5871
PMID:29545830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5840941/
Abstract

The topic of pheochromocytomas is becoming increasingly popular as a result of major advances in different medical fields, including laboratory diagnosis, genetics, therapy, and particularly in novel advances in imaging techniques. The present review article discusses current clinical, biochemical, genetic and histopathological aspects of the diagnosis of pheochromocytomas and planning of pre-surgical preparation and subsequent surgical treatment options. The main part of the paper is focused on the role of morphological imaging methods (primarily computed tomography and magnetic resonance imaging) and functional imaging (scintigraphy and positron emission tomography) in the diagnosis and staging of pheochromocytomas.

摘要

由于包括实验室诊断、遗传学、治疗，尤其是成像技术的新进展在内的不同医学领域取得了重大进展，嗜铬细胞瘤这一主题正变得越来越热门。本综述文章讨论了嗜铬细胞瘤诊断的当前临床、生化、遗传和组织病理学方面，以及术前准备和后续手术治疗方案的规划。本文的主要部分聚焦于形态学成像方法（主要是计算机断层扫描和磁共振成像）和功能成像（闪烁扫描和正电子发射断层扫描）在嗜铬细胞瘤诊断和分期中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/5073de32b8ba/etm-15-04-3151-g17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/84b52334f21e/etm-15-04-3151-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/8848d775ce91/etm-15-04-3151-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/5cbbf94c698e/etm-15-04-3151-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/e83bc5a4882f/etm-15-04-3151-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/5b305e7de34d/etm-15-04-3151-g10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/d1de47e11224/etm-15-04-3151-g11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/2e7c91c52ed9/etm-15-04-3151-g14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/5073de32b8ba/etm-15-04-3151-g17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/84b52334f21e/etm-15-04-3151-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/8848d775ce91/etm-15-04-3151-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/5cbbf94c698e/etm-15-04-3151-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/e83bc5a4882f/etm-15-04-3151-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/5b305e7de34d/etm-15-04-3151-g10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/d1de47e11224/etm-15-04-3151-g11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/2e7c91c52ed9/etm-15-04-3151-g14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e69/5840941/5073de32b8ba/etm-15-04-3151-g17.jpg

相似文献

1
Current diagnostic imaging of pheochromocytomas and implications for therapeutic strategy.嗜铬细胞瘤的当前诊断成像及其对治疗策略的影响。
Exp Ther Med. 2018 Apr;15(4):3151-3160. doi: 10.3892/etm.2018.5871. Epub 2018 Feb 14.
2
Pheochromocytoma: presentation, diagnosis and treatment.嗜铬细胞瘤：临床表现、诊断与治疗
J Hypertens. 2006 Dec;24(12):2331-9. doi: 10.1097/01.hjh.0000251887.01885.54.
3
6-18F-fluoro-L-dihydroxyphenylalanine positron emission tomography is superior to 123I-metaiodobenzyl-guanidine scintigraphy in the detection of extraadrenal and hereditary pheochromocytomas and paragangliomas: correlation with vesicular monoamine transporter expression.6-18F-氟-L-二羟苯丙氨酸正电子发射断层扫描在检测肾上腺外和遗传性嗜铬细胞瘤和副神经节瘤方面优于 123I-间碘苄胍闪烁显像：与囊泡单胺转运体表达的相关性。
J Clin Endocrinol Metab. 2010 Jun;95(6):2800-10. doi: 10.1210/jc.2009-2352. Epub 2010 Apr 6.
4
Quantitative analysis of normal and pathologic adrenal glands with 18F-FDOPA PET/CT: focus on pheochromocytomas.18F-FDOPA PET/CT对正常及病理状态肾上腺的定量分析：聚焦嗜铬细胞瘤
Nucl Med Commun. 2017 Sep;38(9):771-779. doi: 10.1097/MNM.0000000000000708.
5
Advances in the diagnosis and therapy of adrenal tumors.肾上腺肿瘤的诊断与治疗进展
Curr Opin Oncol. 1998 Jan;10(1):52-7. doi: 10.1097/00001622-199801000-00009.
6
Management of incidentally discovered adrenal masses.偶发肾上腺肿块的管理
World J Urol. 1999 Feb;17(1):9-14. doi: 10.1007/s003450050098.
7
Early diagnosis of and surgical strategy for adrenal medullary disease in MEN II gene carriers.MEN II基因携带者肾上腺髓质疾病的早期诊断及手术策略
Surgery. 1988 Jan;103(1):11-8.
8
[Pheochromocytomas as adrenal gland incidentalomas].[嗜铬细胞瘤作为肾上腺偶发瘤]
Srp Arh Celok Lek. 2002 Jul;130 Suppl 2:47-51.
9
Incidental adrenal pheochromocytoma. Report on 5 operated patients and update of the literature.偶发性肾上腺嗜铬细胞瘤。5例手术患者的报告及文献综述
Arch Ital Urol Androl. 2003 Dec;75(4):217-25.
10
Pheochromocytomas and Hypertension.嗜铬细胞瘤与高血压。
Curr Hypertens Rep. 2018 Jan 22;20(1):3. doi: 10.1007/s11906-018-0804-z.

引用本文的文献

1
Point-of-care ultrasound (POCUS) as a key tool in the diagnosis of pheochromocytoma: a case report in an elderly patient with extreme blood pressure variability.床旁超声（POCUS）作为嗜铬细胞瘤诊断的关键工具：一例老年患者血压极度波动的病例报告
Front Med (Lausanne). 2025 Jul 30;12:1525893. doi: 10.3389/fmed.2025.1525893. eCollection 2025.
2
Global epidemiology of pheochromocytoma: a systematic review and meta-analysis of observational studies.嗜铬细胞瘤的全球流行病学：观察性研究的系统评价和荟萃分析
J Endocrinol Invest. 2025 Jul 2. doi: 10.1007/s40618-025-02639-9.
3
Hypertensive retinopathy as the first manifestation of extra-adrenal paraganglioma.

本文引用的文献

1
New Perspectives on Pheochromocytoma and Paraganglioma: Toward a Molecular Classification.《嗜铬细胞瘤和副神经节瘤的新视角：迈向分子分类》
Endocr Rev. 2017 Dec 1;38(6):489-515. doi: 10.1210/er.2017-00062.
2
CT Texture Analysis: Definitions, Applications, Biologic Correlates, and Challenges.CT纹理分析：定义、应用、生物学关联及挑战
Radiographics. 2017 Sep-Oct;37(5):1483-1503. doi: 10.1148/rg.2017170056.
3
Comparison of the 68Ga-DOTATATA PET/CT, FDG PET/CT, and MIBG SPECT/CT in the Evaluation of Suspected Primary Pheochromocytomas and Paragangliomas.
高血压性视网膜病变作为肾上腺外副神经节瘤的首发表现。
Hormones (Athens). 2025 May 28. doi: 10.1007/s42000-025-00675-x.
4
Adrenal pheochromocytoma masquerading as a hydatid cyst: A case report and review of literature.伪装成包虫囊肿的肾上腺嗜铬细胞瘤：一例报告并文献复习
J Minim Access Surg. 2025 Apr 1;21(2):209-213. doi: 10.4103/jmas.jmas_329_23. Epub 2024 Aug 12.
5
A Rare Case Report of Extra-adrenal Pheochromocytoma Masquerading as a Pancreatic Head Malignancy.一例伪装成胰头恶性肿瘤的肾上腺外嗜铬细胞瘤罕见病例报告。
Cureus. 2024 Dec 27;16(12):e76464. doi: 10.7759/cureus.76464. eCollection 2024 Dec.
6
Pheochromocytoma: an updated scoping review from clinical presentation to management and treatment.嗜铬细胞瘤：从临床表现到管理与治疗的最新范围综述
Front Endocrinol (Lausanne). 2024 Dec 13;15:1433582. doi: 10.3389/fendo.2024.1433582. eCollection 2024.
7
Incidental detection of purely cystic pheochromocytoma in a young adult presenting with lower urinary tract infection.一名患有下尿路感染的年轻成年人偶然发现纯囊性嗜铬细胞瘤。
Radiol Case Rep. 2024 Sep 23;19(12):6152-6156. doi: 10.1016/j.radcr.2024.08.144. eCollection 2024 Dec.
8
An Aberrant Case of Pheochromocytoma in a Young Adult Presenting With Secondary Hypertension: A Case Report With Review of the Literature.一名年轻成人嗜铬细胞瘤伴继发性高血压的异常病例：病例报告并文献复习
Cureus. 2023 Sep 8;15(9):e44891. doi: 10.7759/cureus.44891. eCollection 2023 Sep.
9
Histone deacetylase inhibitors as a novel therapeutic approach for pheochromocytomas and paragangliomas.组蛋白去乙酰化酶抑制剂作为一种治疗嗜铬细胞瘤和副神经节瘤的新方法。
Oncol Res. 2023 Feb 3;30(5):211-219. doi: 10.32604/or.2022.026913. eCollection 2022.
10
Calvarial metastasis from malignant pheochromocytoma associated with multiple endocrine neoplasia.恶性嗜铬细胞瘤伴多发性内分泌腺瘤病的颅骨转移
Surg Neurol Int. 2022 Sep 30;13:444. doi: 10.25259/SNI_644_2022. eCollection 2022.
68Ga-DOTATATA PET/CT、FDG PET/CT 和 MIBG SPECT/CT 在疑似原发性嗜铬细胞瘤和副神经节瘤评估中的比较。
Clin Nucl Med. 2017 Jul;42(7):525-529. doi: 10.1097/RLU.0000000000001674.
4
Update on Adrenal Tumours in 2017 World Health Organization (WHO) of Endocrine Tumours.2017 年世界卫生组织（WHO）内分泌肿瘤学肾上腺肿瘤更新。
Endocr Pathol. 2017 Sep;28(3):213-227. doi: 10.1007/s12022-017-9484-5.
5
Differentiating pheochromocytoma from lipid-poor adrenocortical adenoma by CT texture analysis: feasibility study.基于 CT 纹理分析鉴别嗜铬细胞瘤与乏脂性肾上腺皮质腺瘤：一项可行性研究。
Abdom Radiol (NY). 2017 Sep;42(9):2305-2313. doi: 10.1007/s00261-017-1118-3.
6
Malignant pheochromocytoma-paraganglioma: pathogenesis, TNM staging, and current clinical trials.恶性嗜铬细胞瘤 - 副神经节瘤：发病机制、TNM分期及当前临床试验
Curr Opin Endocrinol Diabetes Obes. 2017 Jun;24(3):174-183. doi: 10.1097/MED.0000000000000330.
7
Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma.嗜铬细胞瘤和副神经节瘤的综合分子特征
Cancer Cell. 2017 Feb 13;31(2):181-193. doi: 10.1016/j.ccell.2017.01.001. Epub 2017 Feb 2.
8
Consensus Statement on next-generation-sequencing-based diagnostic testing of hereditary phaeochromocytomas and paragangliomas.遗传性嗜铬细胞瘤和副神经节瘤的下一代测序诊断检测共识声明。
Nat Rev Endocrinol. 2017 Apr;13(4):233-247. doi: 10.1038/nrendo.2016.185. Epub 2016 Nov 18.
9
ADC histogram analysis for adrenal tumor histogram analysis of apparent diffusion coefficient in differentiating adrenal adenoma from pheochromocytoma.肾上腺肿瘤的表观扩散系数（ADC）直方图分析：用于鉴别肾上腺腺瘤与嗜铬细胞瘤的表观扩散系数直方图分析
J Magn Reson Imaging. 2017 Apr;45(4):1195-1203. doi: 10.1002/jmri.25452. Epub 2016 Aug 29.
10
(68)Ga-DOTATATE and (18)F-FDG PET/CT in Paraganglioma and Pheochromocytoma: utility, patterns and heterogeneity.（68）镓-多柔比星和（18）氟-脱氧葡萄糖PET/CT在副神经节瘤和嗜铬细胞瘤中的应用：效用、表现形式及异质性
Cancer Imaging. 2016 Aug 17;16(1):22. doi: 10.1186/s40644-016-0084-2.