Ruiz-Del-Tiempo María Pilar, Calvo Pilar, Ferreras Antonio, Leciñena Jesús, Pablo Luis, Ruiz-Moreno Oscar
Department of Ophthalmology, Gregorio Marañón University General Hospital, Madrid, Spain.
IIS-Aragón, Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain.
J Ophthalmol. 2018 Feb 6;2018:4081874. doi: 10.1155/2018/4081874. eCollection 2018.
To evaluate anatomical retinal changes measured by spectral-domain optical coherence tomography (SD-OCT), after applying photodynamic therapy (PDT) for treatment of chronic central serous chorioretinopathy (CSC).
A retrospective analysis was conducted on 43 patients (48 eyes) with chronic CSC treated with PDT. Visual acuity (VA), central retinal thickness (CRT), outer nuclear layer (ONL) thickness, subretinal fluid (SRF), and photoreceptor ellipsoid zone (EZ) measured by SD-OCT were collected at baseline and at 3, 6, and 12 months after PDT. Differences between normally distributed variables were calculated by a paired-sample -test; < 0.05 was considered statistically significant.
Mean age was 50 ± 9.8 years. Mean time from diagnosis to PDT was 12.5 months. Baseline VA was 0.51 ± 0.24 and significantly improved ( < 0.001) to 0.74 ± 0.26 one year after PDT. CRT and SRF significantly decreased ( < 0.001) at 3, 6, and 12 months after treatment. ONL thickness and EZ did not significantly change at any point during follow-up.
Not significant changes were found in the ONL or EZ 12 months after PDT.
评估采用光动力疗法（PDT）治疗慢性中心性浆液性脉络膜视网膜病变（CSC）后，通过光谱域光学相干断层扫描（SD-OCT）测量的视网膜解剖学变化。
对43例（48只眼）接受PDT治疗的慢性CSC患者进行回顾性分析。在基线以及PDT治疗后3、6和12个月时，收集通过SD-OCT测量的视力（VA）、中心视网膜厚度（CRT）、外核层（ONL）厚度、视网膜下液（SRF）和光感受器椭圆体带（EZ）。通过配对样本t检验计算正态分布变量之间的差异；P<0.05被认为具有统计学意义。
平均年龄为50±9.8岁。从诊断到PDT的平均时间为12.5个月。基线视力为0.51±0.24，PDT治疗一年后显著改善（P<0.001）至0.74±0.26。治疗后3、6和12个月时，CRT和SRF显著降低（P<0.001）。随访期间任何时间点ONL厚度和EZ均无显著变化。
PDT治疗12个月后，ONL或EZ未发现显著变化。
