Scalliet P, Landuyt W, van der Schueren E
C R Seances Soc Biol Fil. 1987;181(1):70-7.
We have investigated the effect of single doses delivered at various dose rates on the mouse lip mucosa biological system. The dose rates were: 642, 76.8, 14.1, 2.9 and 1.5 Gy/h. The incidence of desquamation in the different groups of mice was used for constructing dose effect curves. The dose leading to desquamation in 50% of the animals (ED50) was obtained by probit analysis. These ED50 were 16.5, 16.7, 19, 30.2 and 33.5 Gy for the respective dose rates. Fractionated irradiations have also been performed in the same biological system (separately published), and we have therefore been able to compare the fractionated and low dose rate irradiations. The recently published model of Dale was used for this comparison. With that mathematical approach a alpha/beta value of 7.4 Gy and a half time of repair of sublethal damage of 47 minutes have been derived. These results compare well with others from the literature on biological systems with similar characteristics (rapidly proliferating systems).
我们研究了以不同剂量率给予的单次剂量对小鼠唇部黏膜生物系统的影响。剂量率分别为：642、76.8、14.1、2.9和1.5 Gy/h。不同组小鼠的脱屑发生率用于构建剂量效应曲线。通过概率分析获得导致50%动物出现脱屑的剂量（ED50）。对于相应的剂量率，这些ED50分别为16.5、16.7、19、30.2和33.5 Gy。在相同生物系统中也进行了分次照射（已单独发表），因此我们能够比较分次照射和低剂量率照射。为此比较使用了最近发表的戴尔模型。通过该数学方法得出α/β值为7.4 Gy，亚致死损伤修复的半衰期为47分钟。这些结果与文献中关于具有类似特征（快速增殖系统）的生物系统的其他结果相当吻合。
