降低照射剂量率对小鼠唇黏膜的影响。与分次照射的比较。
Effect of decreasing the dose rate of irradiation on the mouse lip mucosa. Comparison with fractionated irradiations.
作者信息
Scalliet P, Landuyt W, van der Schueren E
机构信息
Department of Experimental Radiotherapy, University Hospital St. Rafaël, Leuven, Belgium.
出版信息
Radiother Oncol. 1987 Sep;10(1):39-47. doi: 10.1016/s0167-8140(87)80068-3.
The effect of continuous irradiation, delivered at five different dose rates (642, 76.8, 14.1, 2.9 and 1.5 Gy.h-1), has been investigated using the mouse lip mucosa. There was a striking dose rate effect (DRE) below 14.1 Gy.h-1 while above this dose rate the DRE was relatively small. No DRE was observed between irradiations delivered at 642 and 76.8 Gy.h-1. A comparison was made with the previously published results of high dose rate (84 Gy.h-1) fractionated irradiation (2, 4, 10 and 20 fractions). For both types of irradiation treatment an alpha/beta value of 7.4 Gy and a half-time for repair of 47 min was derived.
利用小鼠唇部黏膜研究了以五种不同剂量率（642、76.8、14.1、2.9和1.5 Gy·h⁻¹）进行连续照射的效果。在14.1 Gy·h⁻¹以下存在显著的剂量率效应（DRE），而高于此剂量率时，剂量率效应相对较小。在642和76.8 Gy·h⁻¹的照射之间未观察到剂量率效应。将其与先前发表的高剂量率（84 Gy·h⁻¹）分次照射（2、4、10和20次分割）的结果进行了比较。对于这两种照射治疗类型，得出α/β值为7.4 Gy，修复半衰期为47分钟。
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