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Using multiple 'omics strategies for novel therapies in sepsis.

作者信息

Russell James A, Spronk Peter, Walley Keith R

机构信息

Division of Critical Care Medicine, Centre for Heart Lung Innovation, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

Department of ICU, Gelre Hospitals Apeldoorn, Apeldoorn, The Netherlands.

出版信息

Intensive Care Med. 2018 Apr;44(4):509-511. doi: 10.1007/s00134-018-5122-z. Epub 2018 Mar 15.

DOI:10.1007/s00134-018-5122-z

PMID:29546534

Abstract

摘要

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Time to Treatment and Mortality during Mandated Emergency Care for Sepsis.

N Engl J Med. 2017 Jun 8;376(23):2235-2244. doi: 10.1056/NEJMoa1703058. Epub 2017 May 21.

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

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The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9.

Pharmacol Rev. 2017 Jan;69(1):33-52. doi: 10.1124/pr.116.012989.

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287.

PCSK9 is a critical regulator of the innate immune response and septic shock outcome.

Sci Transl Med. 2014 Oct 15;6(258):258ra143. doi: 10.1126/scitranslmed.3008782.

Severe sepsis and septic shock.

N Engl J Med. 2013 Aug 29;369(9):840-51. doi: 10.1056/NEJMra1208623.

Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial.

JAMA. 2013 Mar 20;309(11):1154-62. doi: 10.1001/jama.2013.2194.

Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia.

N Engl J Med. 2012 Nov 15;367(20):1891-900. doi: 10.1056/NEJMoa1201832. Epub 2012 Oct 31.

Effect of a monoclonal antibody to PCSK9 on LDL cholesterol.

N Engl J Med. 2012 Mar 22;366(12):1108-18. doi: 10.1056/NEJMoa1105803.

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相似文献

Using multiple 'omics strategies for novel therapies in sepsis.

Intensive Care Med. 2018 Apr;44(4):509-511. doi: 10.1007/s00134-018-5122-z. Epub 2018 Mar 15.

Sepsis Diagnostics in the Era of "Omics" Technologies.

Prague Med Rep. 2018;119(1):9-29. doi: 10.14712/23362936.2018.2.

The role of genomics to identify biomarkers and signaling molecules during severe sepsis.

Minerva Anestesiol. 2016 Mar;82(3):343-58. Epub 2015 Jun 19.

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Mol Diagn Ther. 2017 Oct;21(5):525-537. doi: 10.1007/s40291-017-0282-z.

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Arch Oral Biol. 2018 Mar;87:15-34. doi: 10.1016/j.archoralbio.2017.12.003. Epub 2017 Dec 8.

"Omics" in pharmaceutical research: overview, applications, challenges, and future perspectives.

Chin J Nat Med. 2015 Jan;13(1):3-21. doi: 10.1016/S1875-5364(15)60002-4.

Maternal sepsis in the era of genomic medicine.

Arch Gynecol Obstet. 2018 Jan;297(1):49-60. doi: 10.1007/s00404-017-4584-5. Epub 2017 Nov 4.

CHO-Omics Review: The Impact of Current and Emerging Technologies on Chinese Hamster Ovary Based Bioproduction.

Biotechnol J. 2018 Mar;13(3):e1700227. doi: 10.1002/biot.201700227. Epub 2017 Nov 15.

Omics for aquatic ecotoxicology: control of extraneous variability to enhance the analysis of environmental effects.

Environ Toxicol Chem. 2015 Aug;34(8):1693-704. doi: 10.1002/etc.3002. Epub 2015 Jun 22.

New stationary phases for enrichment and separation in the 'omics' era.

Bioanalysis. 2009 Apr;1(1):151-69. doi: 10.4155/bio.09.17.

引用本文的文献

Lipidomic profile and candidate biomarkers in septic patients.

Lipids Health Dis. 2020 Apr 13;19(1):68. doi: 10.1186/s12944-020-01246-2.

Discovering Causal Mechanistic Pathways in Sepsis-associated Acute Respiratory Distress Syndrome.

Am J Respir Crit Care Med. 2020 Jan 1;201(1):2-4. doi: 10.1164/rccm.201909-1772ED.

Innovation and safety in critical care: should we collaborate with the industry? Pro.

Intensive Care Med. 2018 Dec;44(12):2276-2278. doi: 10.1007/s00134-018-5306-6. Epub 2018 Nov 8.

本文引用的文献

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis.

N Engl J Med. 2017 Jun 8;376(23):2235-2244. doi: 10.1056/NEJMoa1703058. Epub 2017 May 21.

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

Crit Care Med. 2017 Mar;45(3):486-552. doi: 10.1097/CCM.0000000000002255.

The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9.

Pharmacol Rev. 2017 Jan;69(1):33-52. doi: 10.1124/pr.116.012989.

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287.

PCSK9 is a critical regulator of the innate immune response and septic shock outcome.

Sci Transl Med. 2014 Oct 15;6(258):258ra143. doi: 10.1126/scitranslmed.3008782.

Severe sepsis and septic shock.

N Engl J Med. 2013 Aug 29;369(9):840-51. doi: 10.1056/NEJMra1208623.

Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial.

JAMA. 2013 Mar 20;309(11):1154-62. doi: 10.1001/jama.2013.2194.

Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia.

N Engl J Med. 2012 Nov 15;367(20):1891-900. doi: 10.1056/NEJMoa1201832. Epub 2012 Oct 31.

Effect of a monoclonal antibody to PCSK9 on LDL cholesterol.

N Engl J Med. 2012 Mar 22;366(12):1108-18. doi: 10.1056/NEJMoa1105803.

Human genetics: pleiotropic mutations.

Nat Rev Genet. 2011 Dec 6;13(1):5. doi: 10.1038/nrg3132.

Using multiple 'omics strategies for novel therapies in sepsis.

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