Wingenfeld Katja, Dettenborn Lucia, Kirschbaum Clemens, Gao Wei, Otte Christian, Roepke Stefan
a Klinik für Psychiatrie und Psychotherapie , Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin , Berlin , Germany.
b Department of Medical Psychology , Universitätsklinikum Hamburg Eppendorf , Hamburg , Germany.
Stress. 2018 Jul;21(4):366-369. doi: 10.1080/10253890.2018.1451837. Epub 2018 Mar 16.
Endocannabinoids are involved in depressive and anxious symptoms and might play a role in stress-associated psychiatric disorders. While alterations in the endogenous cannabinoid system have been repeatedly found in patients with posttraumatic stress disorder (PTSD), this system has been mostly neglected in borderline personality disorder (BPD). However, there is first evidence for elevated serum levels of the endocannabinoids arachidonylethanolamide (AEA) and 2-arachidonyl-sn-glycerol (2-AG) in BPD patients compared to healthy controls and PTSD patients. In this study, hair endocannabinoids were analyzed, reflecting long-term endocannabinoid concentrations. We assessed AEA concentrations as well as 2-AG and the 2-AG main isomer 1-AG (1-AG/2-AG) in hair in women with BPD (n = 15) and age- and education-matched healthy women (n = 16). We found significantly reduced log AEA in BPD patients compared to healthy women (p = .03) but no differences in log 1-AG/2-AG concentrations. In addition, there was no association between 1-AG/2-AG and hair cortisol, but we found a non-significant correlation between hair concentrations of AEA and cortisol (p = .06). Our data indicate altered long-term release of endogenous cannabinoids in women with BPD depending on type of endocannabinoid. AEA has been suggested to modulate the basal activity of the endocannabinoid system and seems to attenuate depressive and anxious symptoms. Thus, chronically reduced AEA might contribute to psychiatric symptoms in BPD.
内源性大麻素与抑郁和焦虑症状有关，可能在与压力相关的精神疾病中起作用。虽然在创伤后应激障碍（PTSD）患者中反复发现内源性大麻素系统的改变，但该系统在边缘性人格障碍（BPD）中大多被忽视。然而，有初步证据表明，与健康对照者和PTSD患者相比，BPD患者血清内源性大麻素花生四烯酸乙醇胺（AEA）和2-花生四烯酸甘油酯（2-AG）水平升高。在本研究中，分析了头发中的内源性大麻素，以反映长期内源性大麻素浓度。我们评估了BPD女性患者（n = 15）以及年龄和教育程度匹配的健康女性（n = 16）头发中的AEA浓度以及2-AG和2-AG主要异构体1-AG（1-AG/2-AG）。我们发现，与健康女性相比，BPD患者的log AEA显著降低（p = 0.03），但log 1-AG/2-AG浓度没有差异。此外，1-AG/2-AG与头发皮质醇之间没有关联，但我们发现AEA头发浓度与皮质醇之间存在非显著相关性（p = 0.06）。我们的数据表明，BPD女性患者内源性大麻素的长期释放因内源性大麻素类型而异。有人提出AEA可调节内源性大麻素系统的基础活性，似乎可减轻抑郁和焦虑症状。因此，长期降低的AEA可能导致BPD的精神症状。
