Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, The University of Chicago, Chicago, IL, United States.
Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada.
Psychoneuroendocrinology. 2018 Jun;92:66-71. doi: 10.1016/j.psyneuen.2018.03.009. Epub 2018 Mar 16.
The endocannabinoid (EC) system influences a wide variety of neurobiological processes including affect and emotionality as well as other neuropsychiatric functions. In this study we examined the relationship of circulating endocannabinoids [anandamide (AEA) and 2-arachidonoylglycerol (2-AG)] with affect and emotionality in 175 individuals with (n = 115) and without (n = 60) mood, anxiety, and/or personality disorders. Circulating AEA levels displayed a modest, though statistically significant, inverse relationship with a composite measure of affect regulation (β = - 0.264, p = 0.009), due to its relationship with affect intensity (β = - 0.225, p = 0.021) across all study participants. Neither AEA nor 2-AG level differed as a function of any syndromal/personality disorder and neither correlated significantly with state depression or state anxiety scores. These data suggest that circulating levels endocannabinoids may play a role in emotionality across individuals regardless of defined psychiatric disorder.
内源性大麻素（EC）系统影响广泛的神经生物学过程，包括影响和情绪以及其他神经精神功能。在这项研究中，我们检查了循环内源性大麻素[花生四烯酸乙醇胺（AEA）和 2-花生四烯酰甘油（2-AG）]与 175 名患有（n=115）和不患有（n=60）心境、焦虑和/或人格障碍的个体的影响和情绪之间的关系。循环 AEA 水平与影响调节的综合测量呈适度的负相关关系（β= -0.264，p=0.009），这是由于它与所有研究参与者的影响强度（β= -0.225，p=0.021）有关。AEA 和 2-AG 水平均不受任何综合征/人格障碍的影响，也与状态抑郁或状态焦虑评分无显著相关性。这些数据表明，循环内源性大麻素水平可能在个体的情绪中发挥作用，无论是否存在明确的精神障碍。
