Samanta Sadhanendu, Hajra Alakananda
Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, West Bengal, India.
Chem Commun (Camb). 2018 Mar 29;54(27):3379-3382. doi: 10.1039/C8CC00671G.
A facile and efficient copper-catalyzed cascade annulation of an imidazoheterocycle with salicylaldehyde, piperidine, and terminal alkyne was developed to afford unsymmetrical biheteroaryl derivatives. A variety of biheteroaryl structural motifs containing furans and imidazoheterocycles have been synthesized in ambient air in high yields. The experimental results suggest that the reaction proceeds through a sequential non-radical 5-exo-dig cyclization process.
开发了一种简便高效的铜催化咪唑杂环与水杨醛、哌啶和末端炔烃的串联环化反应，以提供不对称双杂芳基衍生物。在环境空气中以高产率合成了多种含有呋喃和咪唑杂环的双杂芳基结构单元。实验结果表明，该反应通过连续的非自由基5-外向-环化过程进行。
