Tyagi Shivani, Mishra Rakhi, Mazumder Rupa, Mazumder Avijit
Noida Institute of Engineering and Technology (Pharmacy Institute), Knowledge Park-2, Plot 19, Greater Noida, 201306, India.
Curr Mol Med. 2024;24(9):1111-1123. doi: 10.2174/1566524023666230726160056.
Nicotine, minodronic acid, nicotinamide (niacin), zolpidem, zolimidine, and other pyridine-based chemicals play vital roles in medicine and biology. Pyridinecontaining drugs are widely available on the market to treat a wide range of human ailments. As a result of these advances, pyridine research is continually expanding, and there are now higher expectations for how it may aid in the treatment of numerous ailments. This evaluation incorporates data acquired from sources, like PubMed, to provide a thorough summary of the approved drugs and bioactivity data for compounds containing pyridine. Most of the reactions discussed in this article will provide readers with a deeper understanding of various pyridine-related examples, which is necessary for the creation of copper catalysis-based synthetic processes that are more accessible, secure, environmentally friendly, and practical, and that also have higher accuracy and selectivity. This paper also discusses significant innovations in the multi-component copper-catalyzed synthesis of N-heterocycles (pyridine), with the aim of developing precise, cost-effective, and environmentally friendly oxygenation and oxidation synthetic methods for the future synthesis of additional novel pyridine base analogs. Therefore, the review article will serve as a novel platform for researchers investigating copperbased pyridine compounds.
尼古丁、米诺膦酸、烟酰胺（烟酸）、唑吡坦、佐利米定及其他吡啶类化合物在医学和生物学领域发挥着重要作用。含吡啶的药物在市场上广泛供应，用于治疗多种人类疾病。由于这些进展，吡啶研究不断拓展，人们对其在治疗多种疾病方面的帮助也有了更高期望。本评估纳入了从如PubMed等来源获取的数据，以全面总结含吡啶化合物的获批药物及生物活性数据。本文讨论的大多数反应将使读者更深入地了解各种吡啶相关实例，这对于创建更易操作、更安全、更环保、更实用且具有更高准确性和选择性的基于铜催化的合成工艺是必要的。本文还讨论了多组分铜催化合成N - 杂环（吡啶）方面的重大创新，旨在为未来合成更多新型吡啶碱类似物开发精确、经济高效且环保的氧化合成方法。因此，这篇综述文章将为研究基于铜的吡啶化合物的研究人员提供一个新的平台。
