1 Genome Engineering Lab, Division of Plant Biotechnology, SKUAST-K, Shalimar, Jammu & Kashmir-190025, India.
2 The Plant Chemetics Laboratory, Department of Plant Sciences, OX1 3RB South Parks Road, University of Oxford, U.K.; and.
Mol Plant Microbe Interact. 2018 Sep;31(9):889-898. doi: 10.1094/MPMI-12-17-0302-CR. Epub 2018 Jul 27.
Fusarium oxysporum, a ubiquitous soilborne pathogen, causes devastating vascular wilt in more than 100 plant species and ranks 5th among the top 10 fungal plant pathogens. It has emerged as a human pathogen, too, causing infections in immune-compromised patients. Therefore, it is important to gain insight into the molecular processes involved in the pathogenesis of this transkingdom pathogen. A complex network comprising interconnected and overlapping signal pathways-mitogen-activated protein kinase signaling pathways, Ras proteins, G-protein signaling components and their downstream pathways, components of the velvet (LaeA/VeA/VelB) complex, and cAMP pathways-is involved in perceiving the host. This network regulates the expression of various pathogenicity genes. However, plants have evolved an elaborate protection system to combat this attack. They, too, possess intricate mechanisms at the molecular level which, once triggered by pathogen attack, transduce signals to activate defense response. This review focuses on understanding and presenting a wholistic picture of the molecular mechanisms of F. oxysporum-host interactions in plant immunity.
尖孢镰刀菌，一种无处不在的土壤病原体，可引起 100 多种植物物种的毁灭性维管束萎蔫，在十大真菌植物病原体中排名第五。它也已成为人类病原体，导致免疫功能低下的患者感染。因此，深入了解这种跨界病原体的发病机制中的分子过程非常重要。一个由相互连接和重叠的信号通路组成的复杂网络-有丝分裂原激活蛋白激酶信号通路、Ras 蛋白、G 蛋白信号成分及其下游通路、天鹅绒（LaeA/VeA/VelB）复合物的成分和 cAMP 通路-参与感知宿主。该网络调节各种致病性基因的表达。然而，植物已经进化出一种精细的保护系统来对抗这种攻击。它们在分子水平上也拥有错综复杂的机制，一旦受到病原体攻击的触发，就会转导信号以激活防御反应。本综述侧重于理解和呈现植物免疫中尖孢镰刀菌-宿主相互作用的分子机制的整体图景。
