Shanbhag A B, Nevagi S A, Nadkarni V B
Exp Clin Endocrinol. 1987 Mar;89(1):7-15. doi: 10.1055/s-0029-1210621.
The influence of the graded doses of progesterone and progestational antiandrogen, cyproterone acetate, is studied on the vaginal cycles, follicular dynamics and steroidogenic potential of the ovaries and adrenal glands in neonatally androgenised rats with persistent vaginal estrous. Of the different doses of progesterone, 0.5 mg progesterone/day is found to reinstate more or less normal vaginal cycles. None of the doses of progesterone and CPA induced ovulation in cystic ovaries and hence the vaginal cycles thus reinstated are not the reflection of ovarian cycles and the diestrous smear is not an indication of functional CL in these ovaries. The treatment of progesterone and CPA brought about degenerative changes in the antral follicles above stage IV and in cystic type I follicles. It mobilised the growth of type 0 follicles up to the early antral stage of type III, thereby indicating the presence of the negative feedback of progestational steroids on FSH secretion in PVE rats. The minimum change in the activity of carbohydrate metabolising enzymes and the steroid dehydrogenases in the ovaries subsequent to the treatment with especially the higher doses of progesterone, and CPA suggests the absence of any impact on LH secretion, albeit indirect. There was a marked reduction in the steroidogenic potential in the adrenal glands of the CPA treated rats; however, it did not show any positive impact on the structure of the polycystic ovary.
研究了不同剂量的孕酮和孕激素类抗雄激素药物醋酸环丙孕酮对持续性阴道发情的新生期雄激素化大鼠阴道周期、卵泡动态以及卵巢和肾上腺类固醇生成潜能的影响。在不同剂量的孕酮中，发现每天0.5毫克孕酮可使阴道周期或多或少恢复正常。孕酮和醋酸环丙孕酮的任何剂量均未诱导囊性卵巢排卵，因此恢复的阴道周期并非卵巢周期的反映，而间情期涂片也不是这些卵巢中功能性黄体的指标。孕酮和醋酸环丙孕酮治疗导致IV期以上的窦状卵泡和I型囊性卵泡出现退行性变化。它促使0型卵泡生长至III型早期窦状卵泡阶段，从而表明孕激素类类固醇对PVE大鼠促卵泡激素分泌存在负反馈。尤其是高剂量的孕酮和醋酸环丙孕酮治疗后，卵巢中碳水化合物代谢酶和类固醇脱氢酶活性的最小变化表明尽管是间接的，但对促黄体生成素分泌没有任何影响。醋酸环丙孕酮治疗的大鼠肾上腺类固醇生成潜能显著降低；然而，它对多囊卵巢的结构没有任何积极影响。
