Dolles O K, Eriksen H M, Gjermo P
Scand J Dent Res. 1979 Aug;87(4):268-74. doi: 10.1111/j.1600-0722.1979.tb00681.x.
The purpose of the present study was to evaluate the effect of fluoride upon the stain-inducing capacity of chlorhexidine. Ninety-one children, 13 years of age, volunteered for the experiment. Three test dentifrices were used, containing 0.1% NaF, 0.1% NaF + 2% chlorhexidine, and 2% chlorhexidine respectively. The experiment was carried out as a double-blind test, and the degree of staining was recorded after 1 and 2 years. Four methods were used for stain scoring. The results after 1 year showed that chlorhexidine induced less stain when applied together with fluoride than when applied alone. After 2 years this difference disappeared, indicating that fluoride only retarded chlorhexidine-induced staining of teeth.
本研究的目的是评估氟化物对洗必泰致染色能力的影响。91名13岁儿童自愿参与该实验。使用了三种测试牙膏，分别含有0.1%氟化钠、0.1%氟化钠+2%洗必泰以及2%洗必泰。实验采用双盲测试，在1年和2年后记录染色程度。使用了四种方法进行染色评分。1年后的结果表明，与单独使用相比，洗必泰与氟化物一起使用时诱导的染色较少。2年后这种差异消失，表明氟化物仅延缓了洗必泰引起的牙齿染色。
