ACE 插入/缺失多态性与摩洛哥的耐药性高血压呈正相关。

ACE insertion/deletion polymorphism is positively associated with resistant hypertension in Morocco.

机构信息

Genetics and Molecular Pathology Laboratory, Medical School of Casablanca, University Hassan II, 19 Rue Tarik Ibnou Ziad, BP. 9154 Casablanca, Morocco.

Department of Cardiology, Ibn Rochd University Hospital, Casablanca, Morocco.

出版信息

Gene. 2018 Jun 5;658:178-183. doi: 10.1016/j.gene.2018.03.028. Epub 2018 Mar 13.

DOI:10.1016/j.gene.2018.03.028

PMID:29548858

Abstract

OBJECTIVE

The aim of the present study was to investigate the association of I/D polymorphisms of ACE gene is associated with resistant hypertension and essential controlled hypertension.

RESULTS

Our results show that the homozygous mutant genotype DD was more represented among resistant than controlled (58.1% vs 41.9% respectively), however the homozygote wild was more represented among controlled than resistant (70.6% vs 29.4% respectively). But more heterozygous ID among controlled than resistant patients (63.6% vs 36.4% respectively). The difference was statistically significant (p = 0.04). Analysis of clinical parameters indicated that physical activity contributes to resistant hypertension (P < 0.05). Based on our findings, the homozygous mutant for DD of ACE gene is associated with resistant hypertension in our population. Further studies with larger sample sizes are needed to confirm the results of this study.

摘要

目的

本研究旨在探讨 ACE 基因 I/D 多态性与抵抗性高血压和原发性控制高血压的相关性。

结果

我们的结果表明，在抵抗性高血压患者中，纯合突变基因型 DD 比原发性控制高血压患者更为常见（分别为 58.1%和 41.9%），而纯合野生型在原发性控制高血压患者中更为常见（分别为 70.6%和 29.4%）。然而，在原发性控制高血压患者中，杂合子 ID 比抵抗性高血压患者更为常见（分别为 63.6%和 36.4%）。差异具有统计学意义（p=0.04）。临床参数分析表明，体力活动有助于抵抗性高血压（P<0.05）。根据我们的发现，ACE 基因的纯合突变 DD 与我们人群中的抵抗性高血压有关。需要更大样本量的进一步研究来证实本研究的结果。