Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China; Engineering Research Center for Biomaterials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China.
Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China; Engineering Research Center for Biomaterials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China.
Acta Biomater. 2018 Apr 15;71:279-292. doi: 10.1016/j.actbio.2018.03.011. Epub 2018 Mar 14.
Poly (glycerol sebacate) (PGS), a tough elastomer, has been widely explored in tissue engineering due to the desirable mechanical properties and biocompatibility. However, the complex curing procedure (high temperature and vacuum) and limited hydrophilicity (∼90° of wetting angle) greatly impede its functionalities. To address these challenges, a urethane-based low-temperature setting, PEGylated PGS bioelastomer was developed with and without solvent. By simultaneously tailoring PEG and hexamethylene diisocyanate (HDI) contents, the elastomers X-P-mUs (X referred to the PEG content and m referred to HDI content) with a broad ranging mechanical properties and customized hydrophilicity were constructed. The X-P-mUs synthesized exhibited adjustable tensile Young's modulus, ultimate tensile strength and elongation at break in the range of 1.0 MPa-14.2 MPa, 0.3 MPa-7.6 MPa and 53.6%-272.8%, with the water contact angle varying from 28.6° to 71.5°, respectively. Accordingly, these elastomers showed favorable biocompatibility in vitro and mild host response in vivo. Furthermore, the potential applications of X-P-mU elastomers prepared with solvent-base and solvent-free techniques in biomedical fields were investigated. The results showed that these X-P-mU elastomers with high molding capacity at mild temperature could be easily fabricated into various shapes, used as reinforcement for fragile materials, and controllable delivery of drugs and proteins with excellent bioactivity, demonstrating that the X-P-mU elastomers could be tailored as potential building blocks for diverse applications in biomedical research.
Poly(glycerol sebacate) (PGS), a tough biodegradable elastomer, has received great attentions in biomedical field. But the complex curing procedure and limited hydrophilicity greatly hamper its functionality. Herein, a urethane-based low-temperature setting, PEGylated PGS (PEGS-U) bioelastomer with highly-customized mechanical properties, hydrophilicity and biodegradability was first explored. The synthesized PEGS-U showed favorable biocompatibility both in vitro and in vivo. Furthermore, the PEGS-U elastomer could be easily fabricated into various shapes, used as reinforcement for fragile materials, and controllable delivery of drugs and proteins with excellent bioactivity. This versatile, user-tunable bioelastomers should be a promising biomaterials for biomedical applications.
聚（癸二酸丙二醇酯）（PGS）是一种坚韧的弹性体，由于其理想的机械性能和生物相容性，已在组织工程中得到广泛研究。然而，复杂的固化过程（高温和真空）和有限的亲水性（约 90°的润湿角）极大地阻碍了其功能。为了解决这些挑战，开发了一种基于聚氨酯的低温设置、聚乙二醇化 PGS 生物弹性体，有和没有溶剂。通过同时调整聚乙二醇和己二异氰酸酯（HDI）的含量，构建了具有广泛机械性能和定制亲水性的 X-P-mUs 弹性体（X 表示聚乙二醇含量，m 表示 HDI 含量）。合成的 X-P-mUs 表现出可调节的拉伸杨氏模量、拉伸强度和断裂伸长率范围为 1.0 MPa-14.2 MPa、0.3 MPa-7.6 MPa 和 53.6%-272.8%，水接触角分别为 28.6°-71.5°。相应地，这些弹性体在体外表现出良好的生物相容性，在体内表现出温和的宿主反应。此外，还研究了基于溶剂和无溶剂技术制备的 X-P-mU 弹性体在生物医学领域的潜在应用。结果表明，这些在温和温度下具有高成型能力的 X-P-mU 弹性体可以很容易地制成各种形状，用作易碎材料的增强材料，以及可控地输送具有优异生物活性的药物和蛋白质，表明 X-P-mU 弹性体可以作为潜在的构建块，用于生物医学研究中的各种应用。
聚（癸二酸丙二醇酯）（PGS）是一种坚韧的可生物降解弹性体，在生物医学领域受到广泛关注。但是，复杂的固化过程和有限的亲水性极大地阻碍了它的功能。在这里，首次探索了一种基于聚氨酯的低温设置、聚乙二醇化 PGS（PEGS-U）生物弹性体，具有高度定制的机械性能、亲水性和可生物降解性。合成的 PEGS-U 表现出良好的体外和体内生物相容性。此外，PEGS-U 弹性体可以很容易地制成各种形状，用作易碎材料的增强材料，以及可控地输送具有优异生物活性的药物和蛋白质。这种多功能、用户可调的生物弹性体应该是一种有前途的生物材料，可用于生物医学应用。
