Centre of Marine Sciences, University of Algarve, Faculty of Sciences and Technology, Ed. 7, Campus of Gambelas, 8005-139, Faro, Portugal.
University of Antwerp, Natural Products & Food Research and Analysis (NatuRA), Antwerp, Belgium.
Sci Rep. 2018 Mar 16;8(1):4689. doi: 10.1038/s41598-018-23038-6.
This work explored the biotechnological potential of the medicinal halophyte Artemisia campestris subsp. maritima (dune wormwood) as a source of health promoting commodities. For that purpose, infusions, decoctions and tinctures were prepared from roots and aerial-organs and evaluated for in vitro antioxidant, anti-diabetic and tyrosinase-inhibitory potential, and also for polyphenolic and mineral contents and toxicity. The dune wormwood extracts had high polyphenolic content and several phenolics were identified by ultra-high performance liquid chromatography-photodiode array-mass-spectrometry (UHPLC-PDA-MS). The main compounds were quinic, chlorogenic and caffeic acids, coumarin sulfates and dicaffeoylquinic acids; several of the identified phytoconstituents are here firstly reported in this A. campestris subspecies. Results obtained with this plant's extracts point to nutritional applications as mineral supplementary source, safe for human consumption, as suggested by the moderate to low toxicity of the extracts towards mammalian cell lines. The dune wormwood extracts had in general high antioxidant activity and also the capacity to inhibit α-glucosidase and tyrosinase. In summary, dune wormwood extracts are a significant source of polyphenolic and mineral constituents, antioxidants and α-glucosidase and tyrosinase inhibitors, and thus, relevant for different commercial segments like the pharmaceutical, cosmetic and/or food industries.
本研究探索了药用盐生植物黄花蒿（海滨蒿）的生物技术潜力，将其作为具有健康促进作用的商品的来源。为此，从黄花蒿的根和地上部分制备了浸剂、煎剂和酊剂，并评估了它们的体外抗氧化、抗糖尿病和酪氨酸酶抑制潜力，以及多酚和矿物质含量和毒性。海滨蒿提取物具有高多酚含量，通过超高效液相色谱-光电二极管阵列-质谱联用（UHPLC-PDA-MS）鉴定了几种酚类物质。主要化合物为奎宁酸、绿原酸和咖啡酸、香豆素硫酸盐和二咖啡酰奎宁酸；本文首次报道了几种鉴定出的植物成分在这种黄花蒿亚种中存在。该植物提取物的研究结果表明，由于提取物对哺乳动物细胞系的毒性为中低水平，因此可作为安全的人类消费的矿物质补充来源，可应用于营养领域。海滨蒿提取物一般具有较高的抗氧化活性，并且能够抑制α-葡萄糖苷酶和酪氨酸酶。综上所述，海滨蒿提取物是多酚和矿物质成分、抗氧化剂和α-葡萄糖苷酶和酪氨酸酶抑制剂的重要来源，因此与制药、化妆品和/或食品等不同商业领域相关。
