Forrester A W, Joffe S N, Lee F D
Scand J Gastroenterol Suppl. 1979;54:18-22.
This study attempts to compare the endoscopic features of duodenitis with the histological characteristics. During a 12 month period, 98 patients undergoing fibreoptic oesophago-gastro-duodenoscopy had the endoscopic appearances of the duodenum classified on a three point scale of increasing severity of duodenitis. Multiple duodenal biopsies were then taken and the histological features of the severity of duodenitis graded from 0 to 4 plus by an independent observer. The histological criteria included an assessment of neutrophil infiltration, villous bluting, gastric metaplasia and chronic inflammation. Routine endoscopic assessment alone was unsatisfactory for diagnosing and grading the severity of duodenitis and multiple target biopsies are required for histological examinations.
本研究试图比较十二指肠炎症的内镜特征与组织学特征。在12个月期间，98例接受纤维食管-胃-十二指肠镜检查的患者，其十二指肠的内镜表现按十二指肠炎症严重程度增加的三分制进行分类。然后进行多次十二指肠活检，由一名独立观察者将十二指肠炎症严重程度的组织学特征从0级到4级以上进行分级。组织学标准包括对中性粒细胞浸润、绒毛肿胀、胃化生和慢性炎症的评估。仅靠常规内镜评估对十二指肠炎症的诊断和严重程度分级并不令人满意，组织学检查需要进行多次靶向活检。
