工程抗体治疗传染病。

Department of Clinical Laboratory, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing, China.

Adv Exp Med Biol. 2017;1053:207-220. doi: 10.1007/978-3-319-72077-7_10.

Historically, serum therapy was previously used to combat infectious pathogens. However, serum sickness and anaphylaxis limited its broad application. The advancement of antibody engineering technologies has made it feasible to generate monoclonal antibodies. There are divergent methods for antibody engineering and optimization. In this chapter, we summarized the latest developments in engineering antibodies for infectious diseases.

从历史上看，血清疗法曾被用于对抗感染性病原体。然而，血清病和过敏反应限制了其广泛应用。抗体工程技术的进步使得生成单克隆抗体成为可能。抗体工程和优化有不同的方法。在本章中，我们总结了用于传染病的抗体工程的最新进展。