Young M A, Keller M B, Lavori P W, Scheftner W A, Fawcett J A, Endicott J, Hirschfeld R M
J Affect Disord. 1987 Mar-Apr;12(2):139-43. doi: 10.1016/0165-0327(87)90006-1.
The stability of the endogenous subtype of major depressive disorder was examined within individuals across consecutive episodes. The subjects were 119 probands from the NIMH Collaborative Depression Study who experienced at least two episodes of unipolar major depressive disorder within a two-year period of biannual evaluations. Structured data collection methods and Research Diagnostic Criteria were employed. The inter-episode stability of subtype diagnosis was low, never producing a kappa of greater than 0.25. This result was not attributable to threshold for diagnosis, time between episodes, differences in severity, or changes in raters.
在连续发作的个体中研究了重度抑郁症内源性亚型的稳定性。研究对象为美国国立精神卫生研究所协作抑郁症研究中的119名先证者，他们在两年内每半年评估一次，经历了至少两次单相重度抑郁症发作。采用结构化数据收集方法和研究诊断标准。亚型诊断的发作间稳定性较低，kappa值从未超过0.25。这一结果并非归因于诊断阈值、发作间隔时间、严重程度差异或评估者的变化。
