Unit of Cardiac Surgery, Intrathoracic Transplantation and Pulmonary Hypertension, University of Pavia School of Medicine, Foundation IRCCS Policlinico San Matteo, Pavia, Italy; Department of Brain and Behavioral Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy.
Unit of Cardiac Surgery, Intrathoracic Transplantation and Pulmonary Hypertension, University of Pavia School of Medicine, Foundation IRCCS Policlinico San Matteo, Pavia, Italy.
J Heart Lung Transplant. 2018 Jul;37(7):860-864. doi: 10.1016/j.healun.2018.02.007. Epub 2018 Feb 19.
In this prospective, single-center, observational study, we investigated the association between repeated short periods of circulatory arrest with moderate hypothermia during pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and different neuropsychological dimensions.
We examined 70 patients with CTEPH, >18 to 80 years of age, who had been treated with PEA. Neuropsychological testing was performed.
Learning ability and delayed memory remained well within the normal range for patients' age. We found a statistically significant post-surgical improvement in motor speed, which was accompanied by a better quality of life and reduced symptoms of depression and anxiety.
PEA with repeated short periods of circulatory arrest in CTEPH did not result in any neuropsychological complications and may even lead to post-surgical psychological improvements.
在这项前瞻性、单中心、观察性研究中，我们研究了慢性血栓栓塞性肺动脉高压（CTEPH）患者在肺血管内膜剥脱术（PEA）期间多次短暂循环停止并伴有中度低温与不同神经心理学维度之间的关系。
我们检查了 70 名年龄在 18 至 80 岁之间接受 PEA 治疗的 CTEPH 患者。进行了神经心理学测试。
学习能力和延迟记忆仍在患者年龄的正常范围内。我们发现手术后运动速度有统计学意义上的改善，同时生活质量得到提高，抑郁和焦虑症状减轻。
PEA 中多次短暂循环停止并不会导致 CTEPH 患者出现任何神经心理并发症，甚至可能导致手术后心理改善。
