Does the duodenal cell ever return to normal? A comparison between treatment with cimetidine and denol.

After six weeks therapy with the bismuth-containing substance Denol, the ultrastructure of the duodenal cell is normal in most cases. Following therapy with the histamine-2 receptor antagonist (cimetidine), for the same period and even after one year continuous therapy, the denodenal cell remains abnormal in most instances. This may explain the frequent relapse of duodenal ulcers after cimetidine treatment.