用枸橼酸铋钾片（TDB）或西咪替丁治疗后十二指肠溃疡的愈合与复发情况。
Healing and recurrence of duodenal ulcer after treatment with tripotassium dicitrato bismuthate (TDB) tablets or cimetidine.
作者信息
Hamilton I, O'Connor H J, Wood N C, Bradbury I, Axon A T
出版信息
Gut. 1986 Jan;27(1):106-10. doi: 10.1136/gut.27.1.106.
Abstract
Eighty patients with duodenal ulcer were randomly allocated to treatment with tripotassium dicitrato bismuthate (TDB) tablets or cimetidine. Ulcers healed in 78% of patients treated with TDB and in 74% treated with cimetidine, supporting previous observations that the efficacy of these two agents is similar. Duodenal ulcer recurred in 43% of patients in the 12 months after treatment with TDB and in 78% of patients treated with cimetidine, with a significantly greater incidence of recurrence 6-12 months after cimetidine treatment. Tripotassium dicitrato bismuthate tablets may be preferable to cimetidine in the initial management of duodenal ulcer, because they offer a smaller likelihood of recurrence in the 12 months after successful treatment.
摘要
80名十二指肠溃疡患者被随机分配接受三钾二枸橼酸铋（TDB）片或西咪替丁治疗。接受TDB治疗的患者中78%的溃疡愈合，接受西咪替丁治疗的患者中74%的溃疡愈合，这支持了之前关于这两种药物疗效相似的观察结果。在接受TDB治疗后的12个月内，43%的患者十二指肠溃疡复发，而接受西咪替丁治疗的患者中78%复发，西咪替丁治疗后6 - 12个月复发率显著更高。在十二指肠溃疡的初始治疗中，三钾二枸橼酸铋片可能比西咪替丁更可取，因为在成功治疗后的12个月内，其复发可能性更小。
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