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细胞表面T3表达需要T细胞受体的α链和β链同时存在。

Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor.

作者信息

Saito T, Weiss A, Gunter K C, Shevach E M, Germain R N

出版信息

J Immunol. 1987 Jul 15;139(2):625-8.

PMID:2955045
Abstract

We have identified a surface T3- Jurkat variant which has a defective alpha-chain but which possesses an intact beta-chain. The transfection of a functional mouse alpha-chain into this human T cell induces the expression of surface T3 molecules associated with mouse alpha-human beta-heterodimers detected by anticlonotypic antibodies. Treatment of the transfectant with anti-T3, anti-mouse Ti-alpha, or anti-human Ti-beta antibodies clears all Ti-T3 complexes from the surface. These results demonstrate that functional alpha- and beta-chains are both required for expression of T3 on the cell membrane, and that the Ti heterodimers present and associated with T3 on Jurkat cells involve only alpha- and beta-chains.

摘要

我们已鉴定出一种表面T3 - 阴性的Jurkat细胞变体，其α链存在缺陷，但β链完整。将功能性小鼠α链转染到这种人类T细胞中，可诱导表面T3分子的表达，这些T3分子与通过抗独特型抗体检测到的小鼠α - 人类β异二聚体相关。用抗T3、抗小鼠Ti - α或抗人类Ti - β抗体处理转染细胞，可清除表面所有的Ti - T3复合物。这些结果表明，功能性α链和β链对于细胞膜上T3的表达都是必需的，并且Jurkat细胞上存在并与T3相关的Ti异二聚体仅涉及α链和β链。

相似文献

1
Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor.细胞表面T3表达需要T细胞受体的α链和β链同时存在。
J Immunol. 1987 Jul 15;139(2):625-8.
2
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