树突状细胞对CD8 + 细胞毒性T淋巴细胞的直接激活。
Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.
作者信息
Inaba K, Young J W, Steinman R M
出版信息
J Exp Med. 1987 Jul 1;166(1):182-94. doi: 10.1084/jem.166.1.182.
Abstract
Recent experiments (11-13) have shown that antigen-specific, CD8+, CD4- T lymphocytes can be induced to proliferate and become killer cells in the absence of a second population of "helper" CD8-, CD4+ cells. We have studied early events in the activation of CD4+ and CD8+ T cell subsets in the primary mixed leukocyte reaction. Dendritic cells are a major if not essential accessory cell for the activation of both subpopulations. Antigen-bearing macrophages fail to stimulate unprimed CD8+ cells, but act as targets for the sensitized cytolytic lymphocytes that are induced by dendritic cells. The initial proliferative response is comparable for CD4+ and CD8+ lymphocyte subsets. For both subpopulations, dendritic cells efficiently cluster the responding lymphocytes on the first day and induce the release of IL-2. The data indicate that CD4+ and CD8+ lymphocytes can be activated by a similar mechanism, and illustrate the special role of dendritic cells in the sensitization stage of cell-mediated immunity.
摘要
最近的实验（11 - 13）表明，在没有“辅助性”CD8 - 、CD4 + 细胞的第二群体存在的情况下，抗原特异性的CD8 + 、CD4 - T淋巴细胞能够被诱导增殖并成为杀伤细胞。我们研究了初次混合淋巴细胞反应中CD4 + 和CD8 + T细胞亚群激活的早期事件。树突状细胞对于这两个亚群的激活而言，即便不是必需的辅助细胞，也是主要的辅助细胞。携带抗原的巨噬细胞无法刺激未致敏的CD8 + 细胞，但作为树突状细胞诱导产生的致敏溶细胞淋巴细胞的靶细胞。CD4 + 和CD8 + 淋巴细胞亚群的初始增殖反应相当。对于这两个亚群，树突状细胞在第一天就能有效地使反应性淋巴细胞聚集，并诱导白细胞介素 - 2的释放。这些数据表明，CD4 + 和CD8 + 淋巴细胞可以通过类似的机制被激活，并说明了树突状细胞在细胞介导免疫致敏阶段的特殊作用。
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