Couvy-Duchesne Baptiste, O'Callaghan Victoria, Parker Richard, Mills Natalie, Kirk Katherine M, Scott Jan, Vinkhuyzen Anna, Hermens Daniel F, Lind Penelope A, Davenport Tracey A, Burns Jane M, Connell Melissa, Zietsch Brendan P, Scott James, Wright Margaret J, Medland Sarah E, McGrath John, Martin Nicholas G, Hickie Ian B, Gillespie Nathan A
Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
BMJ Open. 2018 Mar 17;8(3):e018959. doi: 10.1136/bmjopen-2017-018959.
The Nineteen and Up study (19Up) assessed a range of mental health and behavioural problems and associated risk factors in a genetically informative Australian cohort of young adult twins and their non-twin siblings. As such, 19Up enables detailed investigation of genetic and environmental pathways to mental illness and substance misuse within the Brisbane Longitudinal Twin Sample (BLTS).
Twins and their non-twin siblings from Queensland, Australia; mostly from European ancestry. Data were collected between 2009 and 2016 on 2773 participants (age range 18-38, 57.8% female, 372 complete monozygotic pairs, 493 dizygotic pairs, 640 non-twin siblings, 403 singleton twins).
A structured clinical assessment (Composite International Diagnostic Interview) was used to collect lifetime prevalence of diagnostic statistical manual (4th edition) (DSM-IV) diagnoses of major depressive disorder, (hypo)mania, social anxiety, cannabis use disorder, alcohol use disorder, panic disorder and psychotic symptoms. Here, we further describe the comorbidities and ages of onset for these mental disorders. Notably, two-thirds of the sample reported one or more lifetime mental disorder.In addition, the 19Up study assessed general health, drug use, work activity, education level, personality, migraine/headaches, suicidal thoughts, attention deficit hyperactivity disorder (ADHD) symptomatology, sleep-wake patterns, romantic preferences, friendships, familial environment, stress, anorexia and bulimia as well as baldness, acne, asthma, endometriosis, joint flexibility and internet use.The overlap with previous waves of the BLTS means that 84% of the 19Up participants are genotyped, 36% imaged using multimodal MRI and most have been assessed for psychological symptoms at up to four time points. Furthermore, IQ is available for 57%, parental report of ADHD symptomatology for 100% and electroencephalography for 30%.
The 19Up study complements a phenotypically rich, longitudinal collection of environmental and psychological risk factors. Future publications will explore hypotheses related to disease onset and development across the waves of the cohort. A follow-up study at 25+years is ongoing.
“19岁及以上”研究（19Up）评估了澳大利亚一个具有遗传信息的年轻成年双胞胎及其非双胞胎兄弟姐妹队列中的一系列心理健康和行为问题以及相关风险因素。因此，19Up能够在布里斯班纵向双胞胎样本（BLTS）中详细研究导致精神疾病和药物滥用的遗传和环境途径。
来自澳大利亚昆士兰州的双胞胎及其非双胞胎兄弟姐妹；大多为欧洲血统。在2009年至2016年期间收集了2773名参与者的数据（年龄范围18 - 38岁，女性占57.8%，372对完全同卵双胞胎，493对异卵双胞胎，640名非双胞胎兄弟姐妹，403名单胎双胞胎）。
采用结构化临床评估（综合国际诊断访谈）收集《精神疾病诊断与统计手册》（第4版）（DSM - IV）中重度抑郁症、（轻）躁狂症、社交焦虑症、大麻使用障碍、酒精使用障碍、惊恐障碍和精神病性症状的终生患病率。在此，我们进一步描述这些精神障碍的共病情况和发病年龄。值得注意的是，三分之二的样本报告有至少一种终生精神障碍。此外，19Up研究还评估了总体健康状况、药物使用情况、工作活动、教育水平、人格、偏头痛/头痛、自杀念头、注意缺陷多动障碍（ADHD）症状、睡眠 - 觉醒模式、浪漫偏好、友谊、家庭环境、压力、厌食症和贪食症以及脱发、痤疮、哮喘、子宫内膜异位症、关节灵活性和互联网使用情况。与BLTS之前各波次研究的重叠意味着19Up研究中84%的参与者已进行基因分型，36%的参与者使用多模态磁共振成像（MRI）进行了成像，并且大多数参与者在多达四个时间点接受了心理症状评估。此外，57%的参与者有智商数据，100%的参与者有父母报告的ADHD症状数据，30%的参与者有脑电图数据。
19Up研究补充了一个在环境和心理风险因素方面具有丰富表型的纵向数据集。未来的出版物将探讨与该队列各波次疾病发病和发展相关的假设。一项针对25岁及以上人群的后续研究正在进行中。
