Carr K E, Joffe S N, Toner P G, Watt C
Scand J Gastroenterol Suppl. 1979;54:78-83.
Using the scanning electron microscope, changes in the rat duodenum have been studied during the healing of gastric secretagogue-induced duodenal ulcers on the 1st, 3rd, 7th and 10th days post-infustion. A montage technique with fine resolution has allowed both the entire area of the duodenum and the cellular organization in individual villi in proximity to the ulcers to be investigated. There was a considerable range of appearances noted at any one time point due to the variations in the size and depth of the original area of ulceration. On day 1, there was acute destruction of the mucosal surface with distortion of the villi at the ulcer margin. By the 3rd day, some specimens already showed full epithelialization over the defects whereas others up to day 10 revealed persistent areas of ulceration. Occasional specimens showed areas suggestive of gastric surface metaplasia on the villous surface adjacent to these ulcers.
利用扫描电子显微镜，对大鼠十二指肠在注入胃促分泌素诱发十二指肠溃疡后第1、3、7和10天愈合过程中的变化进行了研究。一种具有高分辨率的蒙太奇技术使得既能对十二指肠的整个区域进行研究，又能对溃疡附近单个绒毛中的细胞组织进行研究。由于原始溃疡区域大小和深度的变化，在任何一个时间点都观察到了相当多的外观变化。第1天，黏膜表面出现急性破坏，溃疡边缘的绒毛变形。到第3天，一些标本在缺损处已显示完全上皮化，而另一些标本直到第10天仍有持续的溃疡区域。偶尔有标本在与这些溃疡相邻的绒毛表面显示出胃表面化生的区域。
