Kuwajima I, Matsushita S, Kuramoto K
Jpn Heart J. 1987 Mar;28(2):185-91. doi: 10.1536/ihj.28.185.
The correlations between blood pressure, left ventricular hypertrophy and left atrial enlargement were examined in 2,010 autopsied cases. The cases were classified into 3 groups: 972 (48.2%) normotension cases, 313 cases (15.5%) of systolic hypertension and 725 cases (36.1%) of diastolic hypertension. The incidence of left ventricular hypertrophy (LVH) was significantly higher in systolic and diastolic hypertensive cases than in normotensives (p less than 0.05), but no significant difference in LVH incidence was found between the 2 hypertensive groups. The incidence of an enlarged left atrium was also significantly higher in both hypertensive groups than in the normotensive group (p less than 0.05). The incidence of congestive heart failure and a large CTR were also higher in both hypertensive groups. However, there were no intergroup differences in atrial fibrillation incidence, despite significant differences in atrial size. Finally, the incidence of moderate to severe coronary artery stenosis was significantly higher in both hypertensive groups, but no difference was found between the 2 types of hypertension. We concluded that both systolic and diastolic hypertension contributed to the genesis of left ventricular hypertrophy, left atrial dilatation, coronary sclerosis and congestive heart failure.
对2010例尸检病例的血压、左心室肥厚和左心房扩大之间的相关性进行了研究。这些病例被分为3组：972例（48.2%）血压正常病例、313例（15.5%）收缩期高血压病例和725例（36.1%）舒张期高血压病例。收缩期和舒张期高血压病例的左心室肥厚（LVH）发生率显著高于血压正常者（p<0.05），但在这两组高血压病例之间未发现LVH发生率有显著差异。两个高血压组的左心房扩大发生率也显著高于血压正常组（p<0.05）。两个高血压组的充血性心力衰竭发生率和心胸比率也更高。然而，尽管心房大小存在显著差异，但房颤发生率在各组之间没有差异。最后，两个高血压组中重度冠状动脉狭窄的发生率均显著更高，但在两种类型的高血压之间未发现差异。我们得出结论，收缩期和舒张期高血压均促成了左心室肥厚、左心房扩张、冠状动脉硬化和充血性心力衰竭的发生。
