红细胞生成、EPO、巨噬细胞和骨骼。
Erythropoiesis, EPO, macrophages, and bone.
机构信息
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA; Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA.
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA; Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA; Department of Obstetrics & Gynecologic Oncology, Stanford University School of Medicine, Stanford, CA, USA.
出版信息
Bone. 2019 Feb;119:36-41. doi: 10.1016/j.bone.2018.03.014. Epub 2018 Mar 15.
The regulation of erythropoiesis in the bone marrow microenvironment is a carefully orchestrated process that is dependent upon both systemic and local cues. Systemic erythropoietin (EPO) production by renal interstitial cells plays a critical role in maintaining erythropoietic homeostasis. In addition, there is increasing clinical and preclinical data linking changes in EPO and erythropoiesis to altered skeletal homeostasis, suggesting a functional relationship between the regulation of erythropoiesis and bone homeostasis. As key local components of the bone marrow microenvironment and erythropoietic niche, macrophage subsets play important roles in both processes. In this review, we summarize our current understanding of the cellular and molecular mechanisms that may facilitate the coordinated regulation of erythropoiesis and bone homeostasis.
骨髓微环境中红细胞生成的调节是一个精心协调的过程，依赖于全身和局部线索。肾间质细胞产生的系统性促红细胞生成素（EPO）在维持红细胞生成稳态中起着关键作用。此外，越来越多的临床前和临床数据将 EPO 和红细胞生成的变化与骨骼稳态的改变联系起来，表明红细胞生成的调节与骨骼稳态之间存在功能关系。作为骨髓微环境和红细胞生成龛的关键局部成分，巨噬细胞亚群在这两个过程中都发挥着重要作用。在这篇综述中，我们总结了我们目前对可能促进红细胞生成和骨骼稳态协调调节的细胞和分子机制的理解。
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