冠状动脉血流动力学和心脏搏动调节离体Langendorff灌注大鼠心脏心房利钠因子的释放。

Coronary hemodynamics and cardiac beating modulate atrial natriuretic factor release from isolated Langendorff-perfused rat hearts.

作者信息

Naruse M, Higashida T, Naruse K, Shibasaki T, Demura H, Inagami T, Shizume K

出版信息

Life Sci. 1987 Jul 27;41(4):421-7. doi: 10.1016/0024-3205(87)90217-7.

Abstract

The role of coronary hemodynamics and cardiac beating on atrial natriuretic factor (ANF) release was studied in the isolated Langendorff-perfused rat heart. ANF release was measured by radioimmunoassay. When the coronary flow rate was changed, ANF release decreased or increased in a flow-dependent manner. When the perfusion pressure was changed, ANF release also increased or decreased, respectively, with concomitant changes in coronary flow rate. Furthermore, perfusion with 50 mM potassium chloride showed immediate cardiac arrest and a decrease of ANF release to an undetectable level with a significant decrease in coronary flow. However, low but readily detectable amounts of ANF were released when coronary flow rate was maintained. These results may suggest that coronary hemodynamics and cardiac beating could be factors modulating ANF secretion from the atrium.

摘要

在离体Langendorff灌注大鼠心脏中研究了冠状动脉血流动力学和心脏跳动对心房利钠因子（ANF）释放的作用。通过放射免疫测定法测量ANF释放。当冠状动脉流速改变时，ANF释放以流量依赖性方式减少或增加。当灌注压力改变时，ANF释放也分别增加或减少，同时冠状动脉流速发生变化。此外，用50 mM氯化钾灌注显示心脏立即停搏，ANF释放降至不可检测水平，冠状动脉血流显著减少。然而，当冠状动脉流速维持时，会释放少量但易于检测到的ANF。这些结果可能表明冠状动脉血流动力学和心脏跳动可能是调节心房ANF分泌的因素。