Dietz J R
Am J Physiol. 1987 Mar;252(3 Pt 2):R498-502. doi: 10.1152/ajpregu.1987.252.3.R498.
These experiments examined the effects of altering venous return, aortic pressure, or perfusate sodium concentration on the release of atrial natriuretic factor (ANF) from a rat heart-lung preparation. Changes in perfusate ANF concentration during each time period (delta ANF) were used as an index of ANF secretion. Raising the height of the venous return reservoir from 2-3 to 5-7 cm above the heart increased delta ANF from 88 +/- 19 to 748 +/- 154 pg X ml-1 X 10 min-1 (P less than 0.01, n = 7). In control experiments where the height of the reservoir was not increased, delta ANF was unchanged (65 +/- 35 vs. 43 +/- 26 pg X ml-1 X 10 min-1, n = 6). Increasing aortic pressure from 60 to 100 mmHg increased ANF from 43 +/- 10 to 107 +/- 20 pg X ml-1 X 15 min-1 (P less than 0.05, n = 6). Separate groups of heart-lung preparations were perfused with solutions with sodium concentrations of 132 +/- 1, 144 +/- 2, or 166 +/- 1 meq/l (n = 8/group). delta ANF was 45 +/- 14, 50 +/- 17, and 52 +/- 22 pg X ml-1 X 10 min-1, respectively. These values were not significantly different. These results suggest that ANF plays a role in the control of blood volume and blood pressure but do not support a role for ANF in the control of plasma sodium concentration.
这些实验研究了改变静脉回流量、主动脉压力或灌注液钠浓度对大鼠心肺制备物中心房利钠因子（ANF）释放的影响。每个时间段内灌注液ANF浓度的变化（ΔANF）被用作ANF分泌的指标。将静脉回流储液器的高度从心脏上方2 - 3厘米提高到5 - 7厘米，可使ΔANF从88±19增加到748±154 pg·ml⁻¹·10 min⁻¹（P＜0.01，n = 7）。在储液器高度未增加的对照实验中，ΔANF没有变化（65±35与43±26 pg·ml⁻¹·10 min⁻¹，n = 6）。将主动脉压力从60 mmHg增加到100 mmHg，可使ANF从43±10增加到107±20 pg·ml⁻¹·15 min⁻¹（P＜0.05，n = 6）。分别用钠浓度为132±1、144±2或166±1 meq/l的溶液灌注不同组的心肺制备物（每组n = 8）。ΔANF分别为45±14、50±17和52±22 pg·ml⁻¹·10 min⁻¹。这些值没有显著差异。这些结果表明，ANF在血容量和血压控制中起作用，但不支持ANF在血浆钠浓度控制中起作用。
