Mazlin Viacheslav, Xiao Peng, Dalimier Eugénie, Grieve Kate, Irsch Kristina, Sahel José-Alain, Fink Mathias, Boccara A Claude
Institute Langevin, ESPCI PARIS, PSL Research University, 1 Rue Jussieu, Paris, 75005, France.
LLTech SAS, 29 Rue du Faubourg Saint Jacques, Paris, 75014, France.
Biomed Opt Express. 2018 Jan 10;9(2):557-568. doi: 10.1364/BOE.9.000557. eCollection 2018 Feb 1.
We present the first full-field optical coherence tomography (FFOCT) device capable of imaging of the human cornea. We obtained images of the epithelial structures, Bowman's layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemet's membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 µm and relatively large field-of-view of 1.26 mm x 1.26 mm - a combination, which, to the best of our knowledge, has not been possible with other human eye imaging methods. The latter together with a contactless operation, make FFOCT a promising candidate for becoming a new tool in ophthalmic diagnostics.
我们展示了首款能够对人眼角膜进行成像的全场光学相干断层扫描(FFOCT)设备。我们获得了上皮结构、Bowman层、基底神经丛(SNP)、前、后基质角膜细胞、基质神经、Descemet膜和可见细胞核的内皮细胞的图像。图像采集的横向分辨率高达1.7 µm,视野相对较大,为1.26 mm x 1.26 mm——据我们所知,其他人类眼部成像方法无法实现这种组合。后者与非接触式操作一起,使FFOCT成为眼科诊断新工具的一个有前途的候选者。