Xiao Ya-Ping, Zeng Jie, Jiao Lin-Na, Xu Xiao-Yu
College of Pharmaceutical Sciences & Chinese Medicine, Southwest University, Chongqing 400715, China.
Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Chongqing 400715, China.
Zhongguo Zhong Yao Za Zhi. 2018 Jan;43(1):21-30. doi: 10.19540/j.cnki.cjcmm.20171106.002.
The treatment effect and signaling pathway regulation effects of kidney-tonifying traditional Chinese medicine on osteoporosis have been widely studied, but there is no systematic summary currently. This review comprehensively collected and analyzed the traditional Chinese medicines on the treatment and signaling pathway regulation of osteoporosis in recent ten years, such as Epimedii Folium, Drynariae Rhizoma, Cnidii Fructus, Eucommiae Cortex, Psoraleae Fructus and Dipsaci Radix. Based on the existing findings, the following conclusions were obtained: ①kidney-tonifying traditional Chinese medicine treated osteoporosis mainly through BMP-Smads, Wnt/-catenin, MAPK, PI3K/AKT signaling pathway to promote osteoblast bone formation and through OPG/RANKL/ RANK, estrogen, CTSK signaling pathway to inhibit osteoclasts of bone resorption. Epimedii Folium, Drynariae Rhizoma, Cnidii Fructus and Psoraleae Fructus up-regulated the expression of key proteins and genes of BMP-Smads and Wnt/-catenin signaling pathways to promote bone formation. Epimedii Folium, Drynariae Rhizoma, Cnidii Fructus, Eucommiae Cortex, Psoraleae Fructus and Dipsaci Radix inhibited the bone resorption by mediating the OPG/RANKL/RANK signaling pathway. ②Kidney-tonifying traditional Chinese medicine prevented and treated osteoporosis through a variety of ways: icariin in Epimedii Folium, naringin in Drynariae Rhizoma, osthole in Cnidii Fructus and psoralen in Psoraleae Fructus can regulate BMP-Smads, Wnt/-catenin signaling pathway to promote bone formation, but also activate OPG/RANKL/RANK, CTSK and other signaling pathways to inhibit bone resorption. ③The crosstalk of the signaling pathways and the animal experiments of the traditional Chinese medicine on the prevention and treatment of osteoporosis as well as their multi-target mechanism and comprehensive regulation need further clarification.
补肾中药对骨质疏松症的治疗作用及信号通路调控作用已得到广泛研究，但目前尚无系统总结。本综述全面收集并分析了近十年来用于治疗骨质疏松症及调控其信号通路的中药，如淫羊藿、骨碎补、蛇床子、杜仲、补骨脂和续断。基于现有研究结果，得出以下结论：①补肾中药治疗骨质疏松症主要通过BMP-Smads、Wnt/β-catenin、MAPK、PI3K/AKT信号通路促进成骨细胞骨形成，通过OPG/RANKL/RANK、雌激素、CTSK信号通路抑制破骨细胞骨吸收。淫羊藿、骨碎补、蛇床子和补骨脂上调BMP-Smads和Wnt/β-catenin信号通路关键蛋白和基因的表达以促进骨形成。淫羊藿、骨碎补、蛇床子、杜仲、补骨脂和续断通过介导OPG/RANKL/RANK信号通路抑制骨吸收。②补肾中药通过多种方式防治骨质疏松症：淫羊藿中的淫羊藿苷、骨碎补中柚皮苷、蛇床子中蛇床子素和补骨脂中补骨脂素可调节BMP-Smads、Wnt/β-catenin信号通路促进骨形成，还可激活OPG/RANKL/RANK、CTSK等信号通路抑制骨吸收。③信号通路的相互作用以及中药防治骨质疏松症的动物实验及其多靶点机制和综合调控作用尚需进一步阐明。
