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表观遗传学与草药：膝关节骨关节炎的潜在治疗策略

Epigenetics and Herbs: Potential Therapeutic Strategies for Osteoarthritis of the Knee.

作者信息

Zheng Yihui, Wang Jiahui, Wang Lei, Zheng Yang, Qi Wen

机构信息

Department of Medicine, Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine, Nanning, Guangxi, 530222, People's Republic of China.

出版信息

J Pain Res. 2025 Jun 26;18:3217-3261. doi: 10.2147/JPR.S517224. eCollection 2025.

DOI:10.2147/JPR.S517224
PMID:40590047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12208137/
Abstract

Knee osteoarthritis (KOA) is a complex joint disease characterized by progressive cartilage degeneration with programmed cell death of chondrocytes. Programmed cell death (PCD) of chondrocytes plays a central role in the development of knee osteoarthritis, and epigenetics provides new explanations for this complex biological process. By regulating DNA methylation, histone modification and non-coding RNA, epigenetic mechanisms can significantly affect chondrocyte survival and apoptosis without altering the gene sequence. Recent studies have found that TCM can intervene in the epigenetic regulatory network by targeting epigenetic enzymes with active ingredients, non-coding RNA-mediated co-regulation, and epigenetic-metabolic reprogramming. In this paper, we review the latest studies on epigenetics in chondrocyte programmed cell death, focusing on the mechanisms of DNA methylation, histone modification, and non-coding RNAs, such as miRNAs and lncRNAs, and also discuss the interventional roles of TCM in this process, providing therapeutic references to delve into the pathogenesis of KOA.

摘要

膝骨关节炎（KOA）是一种复杂的关节疾病，其特征是软骨进行性退变以及软骨细胞程序性死亡。软骨细胞的程序性死亡（PCD）在膝骨关节炎的发展中起核心作用，而表观遗传学为这一复杂的生物学过程提供了新的解释。通过调节DNA甲基化、组蛋白修饰和非编码RNA，表观遗传机制可在不改变基因序列的情况下显著影响软骨细胞的存活和凋亡。最近的研究发现，中药可以通过活性成分靶向表观遗传酶、非编码RNA介导的共调节以及表观遗传-代谢重编程来干预表观遗传调控网络。在本文中，我们综述了软骨细胞程序性死亡中表观遗传学的最新研究，重点关注DNA甲基化、组蛋白修饰以及miRNA和lncRNA等非编码RNA的机制，并讨论了中药在此过程中的干预作用，为深入探究KOA的发病机制提供治疗参考。

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