Miao Ming-San, Xiang Li-Ling, Bai Ming, Cao Li-Hua
China Association of Traditional Chinese Medicine Pharmacology Specialized Committee, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Zhongguo Zhong Yao Za Zhi. 2018 Jan;43(2):410-414. doi: 10.19540/j.cnki.cjcmm.20171027.010.
Frostbite is a common disease in winter, and systemic or local injury caused by low temperature invasion. Frostbite sites are commonly face, ears, nose, hands, feet and other peripheral blood circulation parts. The main symptoms are pale skin, cold, pain and numbness, skin itching in high temperature, and severe cases may suffer from skin erosions and ulcers. Frostbite model is a pathological model mainly based on Western medicine index. Based on the analysis of clinical symptoms of frostbite in traditional Chinese medicine and western medicine, and a large number of experimental studies on the existing animal models, the animal model preparation of specifications (draft) was formulated as follows.
冻伤是冬季常见疾病，由低温侵袭引起全身或局部损伤。冻伤部位常见于面部、耳朵、鼻子、手、脚等外周血液循环部位。主要症状为皮肤苍白、发冷、疼痛和麻木，在高温时皮肤瘙痒，严重者可能出现皮肤糜烂和溃疡。冻伤模型是一种主要基于西医指标的病理模型。基于对冻伤的中医和西医临床症状分析，以及对现有动物模型的大量实验研究，制定了如下规格（草案）的动物模型制备方法。
