Department of Energy and Resources Engineering, College of Engineering , Peking University , Beijing 100871 , China.
J Org Chem. 2018 Apr 6;83(7):4275-4278. doi: 10.1021/acs.joc.8b00383. Epub 2018 Mar 21.
We describe here an operationally simple and straightforward synthesis method for a series of diverse 4,5-disubstituted 1,2,3-thiadiazoles via the nucleophilic addition of α-diazo carbonyl compounds to carbon disulfide. This method features using abundant and inexpensive carbon disulfide under mild reaction conditions.
我们在这里描述了一种通过α-重氮羰基化合物对二硫化碳的亲核加成来合成一系列不同的 4,5-二取代 1,2,3-噻二唑的操作简单、直接的合成方法。该方法的特点是在温和的反应条件下使用丰富且廉价的二硫化碳。
