Kaufman William S, Ahn Christine S, Huang William W
Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Cutis. 2018 Feb;101(2):136-140.
Molluscum contagiosum (MC) is a common, self-limited cutaneous infection in immunocompetent individuals. However, in immunocompromised individuals the infection often has an atypical presentation and can be difficult to eradicate, making both the diagnosis and treatment challenging. Due to advancements in the management of patients with human immunodeficiency virus (HIV) and cancer, there is a growing population of immunosuppressed individuals, signaling the need for dermatologists to recognize and manage related skin diseases. We present a case of an atypical MC eruption in a patient on biologic therapy for psoriasis and an unrecognized underlying HIV infection, followed by a current review of the presentation and treatment of MC in various immunosuppressed states. With a growing population of immunosuppressed patients, it is important to recognize MC as a potential indicator of underlying immunosuppression. Testing for HIV should be offered to any patient starting immunosuppressive therapy such as biologic agents.
传染性软疣（MC）是免疫功能正常个体中常见的自限性皮肤感染。然而，在免疫功能低下的个体中，感染通常表现不典型且难以根除，这使得诊断和治疗都具有挑战性。由于人类免疫缺陷病毒（HIV）感染者和癌症患者管理方面的进展，免疫抑制个体的数量不断增加，这表明皮肤科医生需要识别和处理相关皮肤疾病。我们报告一例正在接受生物制剂治疗银屑病且未被识别出潜在HIV感染的患者出现非典型MC皮疹的病例，随后对各种免疫抑制状态下MC的表现和治疗进行综述。随着免疫抑制患者数量的增加，将MC识别为潜在免疫抑制指标很重要。对于任何开始免疫抑制治疗（如生物制剂）的患者，都应进行HIV检测。
