Gosnell B A
Physiol Behav. 1987;39(6):687-91. doi: 10.1016/0031-9384(87)90251-4.
Dehydroepiandrosterone (DHEA) is a steroid which has been reported to have anti-obesity effects when added to the diets of rats and mice. In this report, rats made hyperphagic with medial hypothalamic knife cuts were placed on a diet containing 0.45% DHEA or a control diet. Knife cut rats on the control diet ate more food and gained more weight than sham-operated rats on the control diet. In contrast, knife cut rats fed the DHEA diet weighed the same as shams on the DHEA diet and were only observed to be hyperphagic on one of eight 24 hour measurements taken during a five week period. Dietary DHEA reduced food intake and body weight of both knife cut and sham-operated rats, though the effects were smaller in shams. As these effects of DHEA were reminiscent of the effects of dietary quinine adulteration on intake by knife cut rats, a second experiment measured the food intake of unoperated rats when given a choice between a control high-fat diet and one adulterated with various concentrations of DHEA. Even at a concentration of 0.05%, rats clearly identified and avoided the DHEA-adulterated diet. While these results do not rule out effects of DHEA on metabolic rate or lipogenesis, they do indicate that the unpalatability of DHEA-adulterated diets may be a contributing factor in the observed effects on food intake and body weight.
脱氢表雄酮（DHEA）是一种类固醇，据报道，当添加到大鼠和小鼠的饮食中时，它具有抗肥胖作用。在本报告中，用下丘脑内侧刀切法使其食欲亢进的大鼠被置于含有0.45%DHEA的饮食或对照饮食中。食用对照饮食的刀切大鼠比食用对照饮食的假手术大鼠吃更多的食物，体重增加更多。相比之下，喂食DHEA饮食的刀切大鼠的体重与喂食DHEA饮食的假手术大鼠相同，并且在五周期间进行的八次24小时测量中，只有一次观察到它们食欲亢进。饮食中的DHEA降低了刀切大鼠和假手术大鼠的食物摄入量和体重，尽管对假手术大鼠的影响较小。由于DHEA的这些作用让人联想到饮食中掺入奎宁对刀切大鼠摄入量的影响，因此第二项实验测量了未手术大鼠在对照高脂饮食和掺入不同浓度DHEA的饮食之间进行选择时的食物摄入量。即使浓度为0.05%，大鼠也能清楚地识别并避免食用掺入DHEA的饮食。虽然这些结果不能排除DHEA对代谢率或脂肪生成的影响，但它们确实表明，掺入DHEA的饮食的不适口性可能是观察到的对食物摄入量和体重产生影响的一个因素。
