Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China; Guangxi Colleges and Universities Key Laboratory of Human Development and Disease Research, 22 Shuangyong Road, Nanning 530021, Guangxi, China.
Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China; Guangxi Colleges and Universities Key Laboratory of Human Development and Disease Research, 22 Shuangyong Road, Nanning 530021, Guangxi, China; Key Laboratory of Longevity and Aging-Related Diseases (Guangxi Medical University), Ministry of Education, Nanning, China.
Arch Gerontol Geriatr. 2018 May-Jun;76:202-209. doi: 10.1016/j.archger.2018.03.004. Epub 2018 Mar 3.
To look at the possible effect of IGF2R rs9456497 on cardiovascular risks in a long-lived population.
IGF-2R rs9456497 was genotyped by iMLDR for 496 long-lived Zhuang Chinese (90-107 y/o) and their offspring (n = 723, 60-75 y/o) and healthy controls (n = 611, 60-75 y/o). Association analyses were then conducted among genotypes and cardiovascular risks.
The G genotype (GA/GG) was found to represent more frequently in males of general population. No significantly difference was detected among genotypes in each group except that G genotype tended to reduce the systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels in longevity group. However, after sex stratification, total cholesterol (TC) of each genotype in offspring males was elevated versus relevant genotype in longevity and control group; the triglyceride (TG), fasting plasma glucose (FPG) and BMI of each genotype in longevity group were lower while SBP and DBP were higher than that of the relevant genotype in offspring and controls. After stratified by lipid status, the frequency of G allele was markedly increased in the dyslipidemic subgroup in the combined population and controls. Linear regressive analyses showed that HDL was positively correlated to rs9456497 GA genotype while BMI was negatively correlated to AA genotype in offspring group, whereas TC and TG were reversely while BMI was positively associated with AA genotype in CG.
IGF-2R rs9456497 G genotype correlates to detrimental cardiovascular risks in ordinary population which might partially interpret their less preservation of health as compared to long-lived cohort.
研究 IGF2R rs9456497 对长寿人群心血管风险的可能影响。
采用 iMLDR 对 496 名长寿壮族人（90-107 岁）及其后代（n=723，60-75 岁）和健康对照者（n=611，60-75 岁）进行 IGF-2R rs9456497 基因分型。然后在基因型与心血管风险之间进行关联分析。
发现 G 基因型（GA/GG）在普通人群中的男性中更为常见。除长寿组中 G 基因型趋于降低收缩压（SBP）和舒张压（DBP）水平外，各组基因型之间无显著差异。然而，在性别分层后，后代男性的每种基因型的总胆固醇（TC）均高于长寿和对照组的相应基因型；长寿组的每种基因型的甘油三酯（TG）、空腹血糖（FPG）和 BMI 均低于后代和对照组的相应基因型，而 SBP 和 DBP 则高于后者。按血脂状态分层后，在合并人群和对照组的血脂异常亚组中，G 等位基因的频率明显增加。线性回归分析显示，HDL 与 rs9456497 GA 基因型呈正相关，而 BMI 与后代组中的 AA 基因型呈负相关，而 TC 和 TG 与 AA 基因型呈负相关，而 BMI 与 CG 呈正相关。
IGF-2R rs9456497 的 G 基因型与普通人群的心血管不良风险相关，这可能部分解释了他们的健康状况不如长寿人群。
